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Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine

Published online by Cambridge University Press:  16 April 2020

A. Urban ,
J. Libiger ,
L. Hosák  and
K. Kupka
A. Urban*
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
J. Libiger
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
L. Hosák
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
K. Kupka
Affiliation:
Institute of Nuclear Medicine, Charles University, 1st School of Medicine, Prague, Czech Republic
*
2Corresponding author. urban@fnhk.cz
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Abstract

Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS). We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS. Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain. A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way. This helped us to find a proper therapeutic strategy for our patient.

Keywords

SchizophreniaParkinsonismClozapineSPECT
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 258 - 259
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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References

Gerlach, J, Lublin, H, Peacock, L.Extrapyramidal symptoms during long-term treatment with antipsychotics, special focus on clozapine and D1 and D2 dopamine antagonists. Neuropsychopharmacology 1996;14:35S-9S.10.1016/0893-133X(95)00203-PCrossRefGoogle ScholarPubMed
Laakso, A, Bergman, J, Haaparanta, M, Vilkman, H, Solin, O, Syvalahti, E, et al. Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophr Res 2001;52:115–20.10.1016/S0920-9964(00)00095-5CrossRefGoogle ScholarPubMed
Laruelle, M, Abi-Dargham, A, van Dyck, C., Gil, R, D’Souza, DC, Krystal, J, et al. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biol Psychiatry 2000;47:371–9.10.1016/S0006-3223(99)00257-7CrossRefGoogle ScholarPubMed
Lavalaye, J, Linszen, DH, Booij, J, Dingemans, PM, Reneman, L, Habraken, JB, et al. Dopamine transporter density in young patients with schizophrenia assessed with [123I]FP-CIT SPECT. Schizophr Res 2001;47:59–67.10.1016/S0920-9964(00)00023-2CrossRefGoogle Scholar
Schwarz, J, Scherer, J, Trenkwalder, C, Mozley, PD, Tatsch, K.Reduced striatal dopaminergic innervation shown by IPT and SPECT in patients under neuroleptic treatment: need for levodopa therapy? Psychiatry Res 1998;83:23–8.10.1016/S0925-4927(98)00026-2CrossRefGoogle ScholarPubMed
Spivak, M, Mester, R, Abesgaus, J, Winterberg, N, Adlersberg, S, Gonen, N, et al. Clozapine treatment for neuroleptic-induced dyskinesia, parkinsonism, and chronic akathisia in schizophrenic patients. J Clin Psychiatry 1997;58:318–22.CrossRefGoogle ScholarPubMed
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