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Cognitive function in female patients with chronic functional constipation

Published online by Cambridge University Press:  01 September 2022

M. Morozova ,
G. Rupchev ,
A. Alexeev ,
A. Beniashvili ,
S. Potanin ,
D. Burminskiy  and
T. Lepilkina
M. Morozova*
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
G. Rupchev
Affiliation:
Moscow State University, Faculty Of Psychology, Moscow, Russian Federation
A. Alexeev
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
A. Beniashvili
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
S. Potanin
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
D. Burminskiy
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
T. Lepilkina
Affiliation:
FSBI Research Center of Mental Health, Laboratory Of Psychopharmacology, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Chronic functional gastro-intestinal disorders can affect cognitive functioning of patients (1). Wong et al (2) showed attentional and executive function impairment, Aizawa et al. (3) found impairment of cognitive plasticity and activity of frontal and temporal arias of brain during performing tests in these patients.

Objectives

Assessing of cognitive functioning of the female patients with chronic functional constipation.

Methods

42 Rome IV adult female patients with chronic functional constipation and 26 adult normative female volunteers were tested with Brief Assessment of Cognition in Schizophrenia (BACS).

Results

Both groups were comparable by age (patients’ group 29,5±6,1, volunteers’ group 28,5±9,6, ns) In both groups subjects demonstrated normal level of cognitive functioning but the scores of the patients were closer to the lower level than the scores of the volunteers. The difference was significant in composite scores and in several other scores (Tab.1). Table1.

BACSPatients (n=42)Volunteers (n=26)p-level
Verbal Memory49,5± 10,658,8± 7,10,0002
Work memory48,2±10,151,7±8,4ns
Motor token51,3±10,559,8±10,40,003
Verbal fluency52,1±11,556,5±9,9ns
Symbol coding45,1±8,454,8±12,70,015
Tower of London (planning)50,2±10,757,6±10,20,015
Composite scores49,1 ±10,159,9 ±7,40,0001

Conclusions

The findings of the study once more indicate some link between gastrointestinal dysfunction and cognitive functioning. Even these slight decrease in some aspects of cognition from normal population could have negative impact on everyday functioning. The origin of this link is still under question.

Disclosure

No significant relationships.

Keywords

chronic functional constipationfemalecognitive function
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S394
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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