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Clinical features, effectiveness of therapy and quality of life of patients with type 2 diabetes and comorbid schizophrenia

Published online by Cambridge University Press:  13 August 2021

M. Artemieva ,
T. Varnakova ,
I. Danilin ,
A. Lazukova ,
R. Suleimanov  and
V. Sokolov
M. Artemieva*
Affiliation:
Psychiatry And Medical Psychology, RUDN University, Moscow, Russian Federation
T. Varnakova
Affiliation:
Psychiatry, Psychiatry, Moscow, Russian Federation
I. Danilin
Affiliation:
Psychiatry And Medical Psychology, RUDN University, Moscow, Russian Federation
A. Lazukova
Affiliation:
Psychiatry And Medical Psychology, RUDN University, Moscow, Russian Federation
R. Suleimanov
Affiliation:
Psychiatry And Medical Psychology, RUDN University, Moscow, Russian Federation
V. Sokolov
Affiliation:
Psychiatry And Medical Psychology, RUDN University, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

According to previous studies, about 8,8-14,5% cases of schizophrenia is comorbid to type 2 diabetes. The focus of the study was the evaluation and dynamics of positive and negative symptoms in case of combination of the diseases.

Objectives

100 patients were divided in two groups: 48 patients was assigned to receive a monotherapy treatment with antipsychotic; 52 patients received the combination of antipsychotics, nootropics and antioxidants. The efficiency criterion was the dynamics of the questionnaire The quality of life of patients SF- 36, Hamilton’s scale of Depression and anxiety, overall score on a scale for evaluation positive and negative symptoms (PANSS).

Methods

After treatment the physical component of health is 41,38% in the first group and 56,34% in the second group (p≤ 0,05). The psychical component of health is 39,79% in the first group and 50,8% in the second group (p≤ 0,05). Also statistically confirmed (p≤ 0,05) in the patients of the second group the improvement on the Hamilton’s scale of Depression and anxiety questionnaire and PANSS.

Results

After treatment the physical component of health is 41,38% in the first group and 56,34% in the second group (p≤ 0,05). The psychical component of health is 39,79% in the first group and 50,8% in the second group (p≤ 0,05). Also statistically confirmed (p≤ 0,05) in the patients of the second group the improvement on the Hamilton’s scale of Depression and anxiety questionnaire and PANSS.

Conclusions

According to Quality of Life questionnaire combination of antipsychotic, nootropic, antioxidant is significant more effective than treatment only with antipsychotic.

Keywords

Type 2 Diabetesschizophréniaquality of life
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S478
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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