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Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder

Published online by Cambridge University Press:  19 July 2023

H. Ferahkaya ,
O. F. Akca ,
I. Kılınç  and
T. Baysal
H. Ferahkaya
Affiliation:
Child and Adolescent Psychiatry, Dr. Ali Kemal Belviranlı Women and Children’s Hospital
O. F. Akca*
Affiliation:
Child and Adolescent Psychiatry
I. Kılınç
Affiliation:
Biochemistry
T. Baysal
Affiliation:
Pediatric Cardiology, Necmettin Erbakan University Meram School of Medicine, Konya, Türkiye
*
*Corresponding author.

Abstract

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Introduction

Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures.

Objectives

This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.

Methods

A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire and Conner’s Continuous Performance Test. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits.

Results

Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels. (Table 1)Table 2.

Serum claudin-5, occludin, zonulin and tricellulin levels of ADHD and controls

ADHD(n=57)Controls(n=60)Statistical Analysis
ANCOVAc
Mean ± SDMean ± SDz/tpFpηp2
Claudin-5 *(ng/mL)2,14 ± 0,712,47 ± 0,71-3,702P< 0,001a10,1960,0020,083
Occludin*(ng/mL)3,75 ± 7,172,99 ± 2,75-0,136p= 0,892a0,2640,6080,002
Zonulin*(ng/mL)4,82 ± 5,895,06 ± 5,53-0,076p= 0,939a0,0080,930< 0,001
Tricellülin(ng/mL)3,04 ± 0,563,34 ± 0,71-2,552p= 0.012b6,6500,0110,56

Conclusions

These results suggest that claudin-5 and tricellulin may be involved in the etiopathogenesis of ADHD. Alterations in these peptides may affect the brain by leading a dysregulation in intestinal or blood-brain barrier permeability that eventually affects the gut-brain axis. The causal relationship between these peptides and ADHD requires further investigation.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S96 - S97
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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