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Citalopram–induced delusions in an older adult

Published online by Cambridge University Press:  23 March 2020

J. Fennema ,
S. Petrykiv ,
L. De Jonge  and
M. Arts
J. Fennema
Affiliation:
GGZ Friesland, Geriatric Psychiatry, Leeuwarden, The Netherlands
S. Petrykiv
Affiliation:
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands
L. De Jonge
Affiliation:
Leonardo Scientific Research Institute, Department of Geriatric Psychiatry, Groningen, The Netherlands
M. Arts
Affiliation:
University of Groningen, University Medical Center Groningen, Department of Old Age Psychiatry, Groningen, The Netherlands

Abstract

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Introduction

Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants worldwide. In older adults, citalopram is generally well tolerated and safe in the therapeutic dose range of 20 to 40 mg/day. In literature, there are cases of SSRI-induced psychosis, but mainly with fluoxetine. There are only three reported cases of citalopram-induced delusions, however, these case-reports did not involve an older adult.

Objectives and aims

To provide a case of citalopram–induced psychosis in an older adult, followed by the review of available literature.

Methods

A case report is presented and discussed followed by a literature review.

Results

A 64-year-old woman without somatic illnesses was referred by a general practitioner with depressive symptoms. One week after initiation of citalopram 10 mg/day she suddenly developed delusions, predominantly in the early morning. No other medical evidence was found that could explain her delusions. After discontinuation of citalopram her delusions quickly resolved.

Conclusion

This is the first case report of a SSRI-induced delusion in an older adult. Citalopram has been reported to be one of the safest SSRIs. Although most SSRI's have a mild side-effect profile, care should be taken when initiating SSRIs since unpredictable adverse effects may occur.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Psychopharmacology and pharmacoeconomics
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S751 - S752
Copyright
Copyright © European Psychiatric Association 2017
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