Hostname: page-component-848d4c4894-8bljj Total loading time: 0 Render date: 2024-06-24T02:00:55.337Z Has data issue: false hasContentIssue false
  • English
  • Français

Childhood violence experience interacts with BDNF Val158Met polymorphism and modify internet addiction risk

Published online by Cambridge University Press:  01 September 2022

N. Chuprova ,
T. Merkulova ,
M. Solovieva ,
A. Nikolishin ,
A. Trusova ,
S. Grechany ,
V. Soldatkin ,
A. Yakovlev ,
P. Ponizovsky  and
R. Ilyuk
...Show all authors
N. Chuprova*
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Molecular Genetics Laboratory, Moscow, Russian Federation
T. Merkulova
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
M. Solovieva
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
A. Nikolishin
Affiliation:
Federal State Budgetary Istitution Serbsky National Medical Research Centre for Psychiatry and Narcology of Ministry of Heath of the Russian Federation, Laboratory Of Molecular Genetics, Moscow, Russian Federation
A. Trusova
Affiliation:
Saint Petersburg State University, Department Of Medical Psychology And Psychophysiology, Saint Petersburg, Russian Federation
S. Grechany
Affiliation:
Saint Petersburg State Pediatric Medical University, Department Of Psychiatry And Addictology, Saint Petersburg, Russian Federation
V. Soldatkin
Affiliation:
Rostov State Medical University, Department Of Psychiatry, Addictology And Medical Psychology, Rostov-on-Don, Russian Federation
A. Yakovlev
Affiliation:
Lipetsk Regional Addiction Hospital, Department Of Addictology, Lipetsk, Russian Federation
P. Ponizovsky
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Department Of Therapy Of Mental Disorders Complicated By Addiction Diseases, Moscow, Russian Federation
R. Ilyuk
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
A. Egorov
Affiliation:
Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Laboratory Of Neurophysiology And Pathology Of Behavior, St.Petersburg, Russian Federation
E. Krupitsky
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
A. Kibitov
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Molecular Genetics Laboratory, Moscow, Russian Federation
*
*Corresponding author.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Internet-addiction (IA) is one of the most common non-chemical (or behavioral) addictions with genetic impact and substantial effects of psychological and personality characteristics, taking into account the childhood traumatic experience. Gene-environment interactions (GxE) may substantially impact on the risk of Internet-addiction (IA).

Objectives

Aim: to test the associations between the functional polymorphism rs6265 (Val66Met) in brain-derived neurotrophic factor (BDNF) gene, affecting BDNF function, and childhood traumatic experience and their GxE interactions with IA risk.

Methods

In total 456 participants were screened with Chinese Internet Addiction Scale (CIAS) to cut a cohort on two groups: IA (CIAS total score ≥ 65, n=100) and controls (CIAS total score less 64, n=356). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used to assess childhood traumatic experience using its main domains: parents (P), family (F), abuse (A) and violence (V). BDNF Val158Met polymorphism was detected by RT-PCR.

Results

Logistic regression revealed associations of P scores with increased IA risk only after adjustment for sex and age (p=0.01, OR=1.166, 95%CI[1.038-1.309]) and V scores with decreased IA risk (p=0.000, OR=0.799, 95%CI [0,233;0,744] only before adjustment. No associations of F and A with IA risk were found. BDNF Val158Met per se was not associated with IA risk, but significant effect of interaction V score*BDNF rs6265 CC on IA risk in “protective” manner was revealed (р=0.039, OR=0.873, 95%CI[0.768-0.993]) in a model adjusted for sex and age.

Conclusions

Childhood violence experience interacts with BDNF Val158Met polymorphism and CC (ValVal) genotype may be possibly protective factor decreasing the internet addiction risk

Disclosure

This work was carried out with the financial support of the Russian Foundation for Basic Research: RFBR grant # 18-29-22079

Keywords

BDNF Val158Metinternet addictionadverse childhood experiences
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S128
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
Submit a response

Comments

No Comments have been published for this article.