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Cannabis Use and Mania Symptoms: a Systematic Review and Meta-analysis

Published online by Cambridge University Press:  15 April 2020

M. Gibbs ,
C. Winsper ,
S. Marwaha ,
E. Gilbert ,
M. Broome  and
S.P. Singh
M. Gibbs
Affiliation:
Warwick Medical School, University of Warwick, Coventry, United Kingdom
C. Winsper
Affiliation:
Warwick Medical School, University of Warwick, Coventry, United Kingdom
S. Marwaha
Affiliation:
Warwick Medical School, University of Warwick, Coventry, United Kingdom
E. Gilbert
Affiliation:
Warwick Medical School, University of Warwick, Coventry, United Kingdom
M. Broome
Affiliation:
Warneford Hospital, University of Oxford, Coventry, United Kingdom
S.P. Singh
Affiliation:
Warwick Medical School, University of Warwick, Coventry, United Kingdom

Abstract

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Introduction

Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown.

Objectives

This review aimed to examine the impact of cannabis use on the incidence of manic symptoms and on their occurrence in those with pre-existing bipolar disorder

Methods

A systematic review of the scientific literature using the PRISMA guidelines. PsychINFO, Cochrane, Scopus, Embase and MEDLINE databases were searched for prospective studies.

Results

Six articles met inclusion criteria. These sampled 2,391 individuals who had experienced mania symptoms. The mean length of follow up was 3.9 years. Studies support an association between cannabis use and the exacerbation of manic symptoms in those with previously diagnosed bipolar disorder. Furthermore, a meta-analysis of two studies suggests that cannabis use is associated with an approximately 3-fold (Odds Ratio: 2.97; 95% CI: 1.80 to 4.90) increased risk for the new onset of manic symptoms.

Conclusions

Our findings whilst tentative, suggest that cannabis use may worsen the occurrence of manic symptoms in those diagnosed with bipolar disorder and may also act as a causal risk factor in the incidence of manic symptoms. This underscores the importance of discouraging cannabis use among youth and those with bipolar disorder to help prevent chronic psychiatric morbidity. More high quality prospective studies are required to fully elucidate how cannabis use may contribute to the development of mania over time.

Type
Article: 1128
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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