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Associations between long-term lithium treatment and renal, thyroid, and parathyroid function: A register-based study

Published online by Cambridge University Press:  19 July 2023

A. C. Wiuff ,
B. D. Jensen ,
A. A. Nierenberg  and
O. Köhler-Forsberg
A. C. Wiuff*
Affiliation:
Department of Affective Disorders, Aarhus University Hospital - Psychiatry Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
B. D. Jensen
Affiliation:
Department of Affective Disorders, Aarhus University Hospital - Psychiatry
A. A. Nierenberg
Affiliation:
Department of Affective Disorders, Aarhus University Hospital - Psychiatry Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital Harvard Medical School, Boston, United States
O. Köhler-Forsberg
Affiliation:
Department of Affective Disorders, Aarhus University Hospital - Psychiatry Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark
*
*Corresponding author.

Abstract

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Introduction

Although the effect of lithium treatment on kidney and endocrine systems has been extensively investigated, this literature, however, suffers from substantial heterogeneity and many prior studies are limited by short follow-up on just one marker of interest.

Objectives

We aimed to determine the impact of long-term lithium therapy on renal, thyroid and parathyroid function within a large real-world cohort.

Methods

We performed a cohort study within the Central Region of Denmark (approximately 1.3 million inhabitants). Using the Electronic Patient Record system, we identified all patients with at least one serum-lithium (se-Li) measurement in the period from January 1, 2013 to July 20, 2022, and a reference group of patients diagnosed with bipolar disorder (ICD-10: F30, F31) was matched on age, sex and creatinine level. The outcomes were renal, thyroid, and parathyroid function as indicated by all blood tests taken during follow-up measuring creatinine, estimated glomerular filtration rate (eGFR), thyroid-stimulating hormone (TSH), parathyroid hormone (PTH) and calcium. Multilevel regression analyses adjusted for age, sex, severity of the mental disorder (as indicated by the number of hospitalizations), and somatic comorbidity calculated the association between lithium treatment and development in renal, thyroid, and parathyroid function over time.

Results

A total of 4,709 lithium users (61.5% females, median age 46 years [IQR: 32-60]) and 4,027 control individuals were identified with a total follow-up period of 14,686 person-years (median = 1.7 years, range: 1-9.5). Out of the 4,709 lithium users, a total of 3,157 were incident lithium users. The final results will be shown at the 2023 EPA Congress.

Conclusions

The conclusions will be presented at the congress.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S505
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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