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Association Study of the HTR2C, Leptin and Adiponectin Genes and Serum Marker Analyses in Clozapine Treated Long-Term Patients with Schizophrenia

Published online by Cambridge University Press:  15 April 2020

J.-P. Klemettilä ,
O. Kampman ,
N. Seppälä ,
M. Viikki ,
M. Hämäläinen ,
E. Moilanen ,
N. Mononen ,
T. Lehtimäki  and
E. Leinonen
J.-P. Klemettilä*
Affiliation:
Department of Psychiatry, Pitkäniemi Hospital, Tampere University Hospital, 33380Pitkäniemi, Finland
O. Kampman
Affiliation:
School of Medicine, University of Tampere, 33014Tampere, Finland Department of Psychiatry, Seinäjoki Hospital District, 60220Seinäjoki, Finland
N. Seppälä
Affiliation:
Department of Psychiatry, Satakunta Hospital District, 28500Pori, Finland
M. Viikki
Affiliation:
School of Medicine, University of Tampere, 33014Tampere, Finland Tampere Mental Health Centre, Hallituskatu 8B, 33200Tampere, Finland
M. Hämäläinen
Affiliation:
The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014Tampere, Finland
E. Moilanen
Affiliation:
The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014Tampere, Finland
N. Mononen
Affiliation:
Fimlab Laboratories, Department of Clinical Chemistry, School of Medicine, University of Tampere, 33014Tampere, Finland
T. Lehtimäki
Affiliation:
Fimlab Laboratories, Department of Clinical Chemistry, School of Medicine, University of Tampere, 33014Tampere, Finland
E. Leinonen
Affiliation:
Department of Psychiatry, Pitkäniemi Hospital, Tampere University Hospital, 33380Pitkäniemi, Finland School of Medicine, University of Tampere, 33014Tampere, Finland
*
*Corresponding author. Department of Psychiatry, Pitkäniemi Hospital, Tampere University Hospital, 33380 Pitkäniemi, Finland. Tel.: +358 50 5928308. E-mail address:jari-pekka.klemettila@pshp.fi (J.-P. Klemettilä).
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Abstract

Clozapine treatment is associated with weight gain and cardio-metabolic consequences among patients with schizophrenia. Polymorphisms of leptin, serotonin receptor HTR2 C and adiponectin genes have been associated with antipsychotic-induced weight gain and metabolic comorbidity. However, the results of the studies so far are inconclusive. The aim of the present study was first to test for a possible role of serum leptin and adiponectin levels as a marker of weight gain in association with inflammatory cytokines/adipokines (IL-6, IL-1Ra, hs-CRP and adipsin), and second to study associations between SNPs LEP rs7799039 (-2548 A/G), ADIPOQ rs1501299 and HTR2 C rs1414334 and weight gain and levels of leptin and adiponectin, in 190 patients with schizophrenia on clozapine treatment, with retrospectively assessed weight change and cross-sectionally measured cytokine levels. A strong association was found between serum levels of leptin and weight gain and cytokines/adipokines related to metabolic comorbidity, especially among female patients (in women leptin vs. weight gain, IL-6 and IL-1Ra, P < 0.001; in men leptin vs. weight gain, P = 0.026, leptin vs. IL-1Ra, P < 0.001). In male patients low adiponectin level was a more specific marker of clozapine-induced weight gain (P = 0.037). The results of the present study do not support a major role of SNPs LEP rs7799039, ADIPOQ rs1501299 and HTR2 C rs1414334 in the regulation of weight gain or association of serum levels of leptin and adiponectin and corresponding studied SNPs in patients with schizophrenia on clozapine treatment.

Keywords

AdipsinAdipokineCytokiners1414334rs7799039rs1501299Weight gain
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 2 , February 2015 , pp. 296 - 302
Copyright
Copyright © Elsevier Masson SAS 2014

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