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Association Study of the HTR2C, Leptin and Adiponectin Genes and Serum Marker Analyses in Clozapine Treated Long-Term Patients with Schizophrenia

  • J.-P. Klemettilä (a1), O. Kampman (a2) (a3), N. Seppälä (a4), M. Viikki (a2) (a5), M. Hämäläinen (a6), E. Moilanen (a6), N. Mononen (a7), T. Lehtimäki (a7) and E. Leinonen (a1) (a2)...


Clozapine treatment is associated with weight gain and cardio-metabolic consequences among patients with schizophrenia. Polymorphisms of leptin, serotonin receptor HTR2 C and adiponectin genes have been associated with antipsychotic-induced weight gain and metabolic comorbidity. However, the results of the studies so far are inconclusive. The aim of the present study was first to test for a possible role of serum leptin and adiponectin levels as a marker of weight gain in association with inflammatory cytokines/adipokines (IL-6, IL-1Ra, hs-CRP and adipsin), and second to study associations between SNPs LEP rs7799039 (-2548 A/G), ADIPOQ rs1501299 and HTR2 C rs1414334 and weight gain and levels of leptin and adiponectin, in 190 patients with schizophrenia on clozapine treatment, with retrospectively assessed weight change and cross-sectionally measured cytokine levels. A strong association was found between serum levels of leptin and weight gain and cytokines/adipokines related to metabolic comorbidity, especially among female patients (in women leptin vs. weight gain, IL-6 and IL-1Ra, P < 0.001; in men leptin vs. weight gain, P = 0.026, leptin vs. IL-1Ra, P < 0.001). In male patients low adiponectin level was a more specific marker of clozapine-induced weight gain (P = 0.037). The results of the present study do not support a major role of SNPs LEP rs7799039, ADIPOQ rs1501299 and HTR2 C rs1414334 in the regulation of weight gain or association of serum levels of leptin and adiponectin and corresponding studied SNPs in patients with schizophrenia on clozapine treatment.


Corresponding author

*Corresponding author. Department of Psychiatry, Pitkäniemi Hospital, Tampere University Hospital, 33380 Pitkäniemi, Finland. Tel.: +358 50 5928308. E-mail (J.-P. Klemettilä).


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Association Study of the HTR2C, Leptin and Adiponectin Genes and Serum Marker Analyses in Clozapine Treated Long-Term Patients with Schizophrenia

  • J.-P. Klemettilä (a1), O. Kampman (a2) (a3), N. Seppälä (a4), M. Viikki (a2) (a5), M. Hämäläinen (a6), E. Moilanen (a6), N. Mononen (a7), T. Lehtimäki (a7) and E. Leinonen (a1) (a2)...


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Association Study of the HTR2C, Leptin and Adiponectin Genes and Serum Marker Analyses in Clozapine Treated Long-Term Patients with Schizophrenia

  • J.-P. Klemettilä (a1), O. Kampman (a2) (a3), N. Seppälä (a4), M. Viikki (a2) (a5), M. Hämäläinen (a6), E. Moilanen (a6), N. Mononen (a7), T. Lehtimäki (a7) and E. Leinonen (a1) (a2)...
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