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Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder

Published online by Cambridge University Press:  01 September 2022

A. Toll ,
M. Portella ,
P. Robledo ,
M. Barrera-Conde ,
R. De La Torre ,
J.M. Ginés ,
C. Diez-Aja ,
V. Soria ,
P. Lopez-Garcia  and
V. Pérez-Solà
...Show all authors
A. Toll*
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
M. Portella
Affiliation:
Hospital de la Santa Creu i Sant Pau, Psychiatry, Barcelona, Spain
P. Robledo
Affiliation:
Universitat Pompeu Fabra, Neuropharmacology Laboratory, Barcelona, Spain
M. Barrera-Conde
Affiliation:
Universitat Pompeu Fabra, Neuropharmacology Laboratory, Barcelona, Spain
R. De La Torre
Affiliation:
Universitat Pompeu Fabra, Neuropharmacology Laboratory, Barcelona, Spain
J.M. Ginés
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
C. Diez-Aja
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
V. Soria
Affiliation:
Hospital de Bellvitge, Psychiatry, Hospitalet de Llobregat, Spain
P. Lopez-Garcia
Affiliation:
Hospital de Bellvitge, Psychiatry, Hospitalet de Llobregat, Spain
V. Pérez-Solà
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
P. Alvarez
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

Inflammation and neural plasticity play a significant role in major depressive disorder (MDD) pathogenesis and cognitive dysfunction. The olfactory neuroepithelium (ON), closely related to the central nervous system (CNS), allows a non-invasive, low-cost study of neuropsychiatric disorders. However, few studies have used ON cells to ascertain them as biomarkers for MDD.

Objectives

Determine the relationship between inflammatory/neural plasticity markers and cognitive functioning in MDD patients and healthy controls.

Methods

Sample: 9 MDD patients and 7 healthy controls. Exclusion criteria: other Axis I mental disorders (patients) or any mental disorder (controls) and any inflammatory, autoimmune, or CNS diseases. Assessment: sociodemographic, clinical, and cognitive variables (CANTAB) were recorded. mRNA was isolated from ON cells and MAPK14, IL6, TNF-α, Mecp2, BDNF, GSK3, GRIA2, and FosB gene expression levels were quantified using quantitative polymerase chain reaction.

Results

MDD patients showed decreased levels of BDNF (p=0.022), GSK3 (p=0.027), and working memory (p=0.024) compared with healthy controls. In healthy controls, planning was positively correlated with NRF2, BDNF, and MAPK14 gene expression. In MDD patients no correlation between cognitive parameters and inflammation/neural plasticity biomarkers was found.

Conclusions

These results reveal that: (1) Plasticity biomarkers such as BDNF and GSK3 could be useful diagnostic tools for MDD (2) MDD is associated with working memory deficits; (3) no association could be determined between planning and NRF2, BDNF, and MAPK14 gene expression in MDD and (4) the ON is a promising model in the study of neuropsychiatric disorders.

Disclosure

No significant relationships.

Keywords

biomarkerscognitioninflammationDepression
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S552
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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