A conception of a mental health is treated very ambiguous. Along with this an assessment of treatment efficacy for mentally ill persons includes a significant number of criteria which are changed continuously in time. Always there is a number of factors influencing on a development, course and outcome of disease. All of them might be considered as predictors of treatment efficacy and must be taken into account in a choice of criteria for therapeutic efficacy.

At the “Institute of Neurology, Psychiatry, and Narcology of the AMS of Ukraine” State Institution an investigation of 184 patients with neurotic disorders had been performed with analysis of predictors of therapeutic efficacy and on the base of data obtained criteria for assessment of treatment efficacy were improved. 81 male and 103 female patients from 18 to 60 years old were examined.

Clinical-psychopathological and pathopsychological predictors with a negative and positive influence on therapeutic efficacy were defined. The most significant of them were included into an integrative index of therapeutic efficacy for patients with neurotic disorders. It consists of such parameters as structure of psychopathological manifestations, level of psychotrauma generalization, level of compliance between the patient and his/her physician and surrounding, peculiarities of personality accentuations, level of a subjective self-control, patient's anxiety and rigidity, importance of a social and personal self-realization, type of attitude to the disease. These actual issues must be taken into account in a psychotherapeutic process. That will allow to increase its efficacy and to prevent recurrence of the disease.