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Apathy correlates with dopamine uptake in neurodegenerative diseases. a spect study with partial volume effect correction

Published online by Cambridge University Press:  16 April 2020

R. David ,
M. Koulibaly ,
J. Darcourt  and
P.H. Robert
R. David
Affiliation:
Research and Memory Center, Department of Psychiatry, Pasteur Hospital, Nice, France
M. Koulibaly
Affiliation:
Department of Nuclear Medecine, Pasteur Hospital, Nice, France
J. Darcourt
Affiliation:
Department of Nuclear Medecine, Pasteur Hospital, Nice, France
P.H. Robert
Affiliation:
Research and Memory Center, Department of Psychiatry, Pasteur Hospital, Nice, France

Abstract

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Apathy is present in several neuropsychiatric diseases. The main purpose of the study was to stress the relationship between apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or Dementia with Lewy body (DLB).

Methods:

22 patients were included.

All patients had neuropsychological and behavioural examination including Mini Mental Test (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (IA). Patients DA striatal uptake were assessed by 123I-FP-CIT (DaTSCAN®) SPECT. A method of quantitative 3D measurement was used in order to allow a precise quantification of modifications affecting striatal cerebral structures.

Results:

The two diagnostic subgroups were equivalent in term of age and MMSE score.

There were no correlations between the NPI delusion, hallucination, depression and anxiety score with DA uptake. There was a significant correlation between the IA total score and the bilateral putamen DA uptake. More specifically, lack of initiative significantly correlated with bilateral putamen DA uptake, whereas lack of interest significantly correlated with left caudate DA uptake. The UPDRS score was significantly correlated with left putamen and caudate DA uptake.

Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative with right putamen DA uptake and left putamen DA uptake.

Conclusion:

These results indicate that there is a relation between apathy and DA uptake, independent of motor activity.

Type
Poster Session 2: Organic Mental Disorders and Memory and Cognitive Dysfunctions
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S298
Copyright
Copyright © European Psychiatric Association 2007
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