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Adverse childhood experience referring to parental relationship is associated with the risk of alcohol dependence and with COMT Val158Met polymorphism, but out of gene-environment interactions

Published online by Cambridge University Press:  01 September 2022

T. Merkulova ,
N. Chuprova ,
M. Solovieva ,
A. Nikolishin ,
A. Kibitov ,
S. Grechany ,
N. Baranok ,
K. Rybakova ,
V. Soldatkin  and
A. Yakovlev
...Show all authors
T. Merkulova*
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
N. Chuprova
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
M. Solovieva
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
A. Nikolishin
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
A. Kibitov
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
S. Grechany
Affiliation:
Saint Petersburg State Pediatric Medical University, Department Of Psychiatry And Addictology, Saint Petersburg, Russian Federation
N. Baranok
Affiliation:
Murmansk Regional Addiction Hospital, Rehabilitation Center, Murmansk, Russian Federation
K. Rybakova
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
V. Soldatkin
Affiliation:
Rostov State Medical University, Department Of Psychiatry, Addictology And Medical Psychology, Rostov-on-Don, Russian Federation
A. Yakovlev
Affiliation:
Lipetsk Regional Addiction Hospital, Department Of Addictology, Lipetsk, Russian Federation
A. Trusova
Affiliation:
Saint Petersburg State University, Department Of Medical Psychology And Psychophysiology, Saint Petersburg, Russian Federation
P. Ponizovsky
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Department Of Therapy Of Mental Disorders Complicated By Addiction Diseases, Moscow, Russian Federation
E. Krupitsky
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Gene-environment interactions (GxE) are considered to make a substantial impact on the risk of alcohol dependence (AD).

Objectives

The aim of the study: to test the associations between the functional polymorphism Val158Met (rs6265) in the catechol-O-methyl transferase (COMT) gene, affecting dopamine neurotransmission, and adverse childhood experiences (ACE) and their GxE interactions with AD risk.

Methods

The study included 149 AD inpatients (mean age 29.9 (SD=3.91), 16.1% females) and 201 healthy volunteers (23.3 (2.48), 30.1% females). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used for assessing ACE. COMT Val158Met polymorphism was detected by RT-PCR.

Results

First, COMT Val158Met polymorphism was associated only with adverse childhood experience referring o parental relationship (ACE-IQ), but differently in two groups. Healthy minor Met158 carriers have lower scores on the subscale “relationship with parents/guardians” (P) (p=0.025) and “physical neglect” (PN) (p=0.059) vs. homozygous Val158 carriers. However, AD patients - Met158carriers have a tendency to a higher score on the subscale “one or no parents, parental separation or divorce” (PSD) (p=0.078). Then logistic regression revealed associations of these ACE scores with increased AD risk: P (p=0.001, OR=1.186, 95%CI [1.069-1.315]), PN (p=0.024, OR=1.254, 95%CI [1.030-1.526]), and PSD (p=0.016, OR=1.499, 95%CI [1.080-2.082]). No associations of COMT Val158Met alone or in interactions with these ACE-IQ scores with the AD risk were found.

Conclusions

Adverse childhood experience referring to parental relationship is associated with alcohol dependence risk and separately with COMT Val158Met, but no clear interactions in frame of GxE has been supported.

Disclosure

No significant relationships.

Keywords

Alcohol dependenceGxE interaction
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S127
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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