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Adherence to antidepressant treatment in depressive patients with comorbid psychiatric disorders

Published online by Cambridge University Press:  16 April 2020

M. Roca ,
S. Armengol ,
M. García-García ,
J. Salva ,
S. Monzón ,
N. Bauzá  and
M. Gili
M. Roca
Affiliation:
Rediapp (Red de Investigación en Actividades Preventivas y de Promoción de la Salud), Madrid, Spain IUNICS (Institut Universitari d’Investigació en Ciencies de la Salut), Barcelona, Spain Unit of Psychiatry and Clinical Psychology Juan March Hospital, University of Balearic Islands, Mallorca, Spain
S. Armengol
Affiliation:
Almirall Medical Department, Barcelona, Spain
M. García-García
Affiliation:
Adknoma Health Research, Barcelona, Spain
J. Salva
Affiliation:
Rediapp (Red de Investigación en Actividades Preventivas y de Promoción de la Salud), Madrid, Spain IUNICS (Institut Universitari d’Investigació en Ciencies de la Salut), Barcelona, Spain
S. Monzón
Affiliation:
Rediapp (Red de Investigación en Actividades Preventivas y de Promoción de la Salud), Madrid, Spain IUNICS (Institut Universitari d’Investigació en Ciencies de la Salut), Barcelona, Spain Unit of Psychiatry and Clinical Psychology Juan March Hospital, University of Balearic Islands, Mallorca, Spain
N. Bauzá
Affiliation:
Rediapp (Red de Investigación en Actividades Preventivas y de Promoción de la Salud), Madrid, Spain IUNICS (Institut Universitari d’Investigació en Ciencies de la Salut), Barcelona, Spain Unit of Psychiatry and Clinical Psychology Juan March Hospital, University of Balearic Islands, Mallorca, Spain
M. Gili
Affiliation:
Rediapp (Red de Investigación en Actividades Preventivas y de Promoción de la Salud), Madrid, Spain IUNICS (Institut Universitari d’Investigació en Ciencies de la Salut), Barcelona, Spain

Abstract

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Background

Depression is associated with high rates of comorbidity with other psychiatric disorders. Adherence to antidepressant medication regimens has been associated to different factors. Few studies have analyzed the influence of comorbid psychiatric disorders and adjunctive pharmacological treatments on antidepressant adherence.

Aim

The study evaluates the association of comorbid psychiatric disorder and pharmacological treatments with adherence rates to antidepressants in a large sample of depressive outpatients.

Method

3606 depressive patients were included in a cross-sectional epidemiological study, involving a stratified sample of 750 psychiatrists selected to participate. Patients were included if they met DSM-IV criteria for current single or recurrent non-psychotic major depressive disorder. Simplified Medication Adherence Questionnaire (SMAQ) and Hamilton Depression Rating Scale (HDRS) were used to assess adherence and depression severity.

Results

Adherence rates are lower in depressive patients with psychiatric comorbidity (62.8%) than in patients without comorbidity (69.1%) (Chi-square = 15.9, p < 0.001, OR = 1.6, 1.2–1.8). There are no significant differences in adherence rates between those patients taking or not benzodiacepines.

Conclusions

Psychiatric comorbidity plays a negative role in adherence to antidepressant treatment. Benzodiazepine use has no influence on adherence rates. Special attention should be paid to the symptom overlapping between anxiety and depression and to the benzodiazepine prescription in comorbid depressive patients.

Type
P03-108
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1277
Copyright
Copyright © European Psychiatric Association 2011
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