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Acute citalopram administration may disrupt contextual information processing in healthy males

Published online by Cambridge University Press:  16 April 2020

S. Almeida ,
D.C. Glahn ,
S.V. Argyropoulos  and
S. Frangou
S. Almeida
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, King's College London, De Crespigny Park, LondonSE5 8AF, UK
D.C. Glahn
Affiliation:
Department of Psychiatry, Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Yale University School of Medicine, Whitehall Residence Building, IOL, Room 202, 200 Retreat avenue, Hartford CT06106, UK
S.V. Argyropoulos*
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, King's College London, De Crespigny Park, LondonSE5 8AF, UK
S. Frangou
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, King's College London, De Crespigny Park, LondonSE5 8AF, UK
*
*Corresponding author. Tel.: +44 207 848 0425; fax: +44 207 848 0903. E-mail address: Spilios.Argyropoulos@kcl.ac.uk (S.V. Argyropoulos).
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Abstract

Selective serotonin reuptake inhibitors (SSRI) are the most commonly prescribed antidepressants. It has been suggested however that SSRI administration may affect response inhibition and contextual processing but the available evidence is minimal. Therefore, the purpose of this study was to identify the effect size of acute (within 24 hours) and chronic (28 days) administration of the highly selective SSRI, Citalopram, compared to placebo on response inhibition (measured by the Degraded Symbol Continuous Performance Task [DS-CPT]) and contextual processing (assessed using a Delayed Non-Matching to Sample Task [DNMS]) in healthy males (n = 20) using a randomised double-blind design. We found no effect of Citalopram on participants’ performance on the DS-CPT which suggests either that SSRIs do not affect response inhibition or that this measure is insensitive to any potential disinhibition effects of SSRI. Acute, but not chronic, Citalopram administration was associated with a measurable decrement in the DNMS suggestive of a negative impact of SSRI administration on contextual processing at least during treatment initiation. These findings provide a useful guide for designing future studies in clinical populations.

Keywords

AntidepressantCitalopramResponse inhibitionContextual processing
Type
Original articles
Information
European Psychiatry , Volume 25 , Issue 2 , March 2010 , pp. 87 - 91
Copyright
Copyright © Elsevier Masson SAS 2010

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