Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-07-03T11:15:36.588Z Has data issue: false hasContentIssue false
  • English
  • Français

Forebrain dopamine systems — can they help us to understand psychosis?

Published online by Cambridge University Press:  16 April 2020

Anthony Grace
Anthony Grace*
Affiliation:
Departments of Neuroscience, Psychiatry and Psychology, 458 Crawford Hall, University of Pittsburgh, Pittsburgh, PA15260USA
*
*E-mail address:grace@bns.pitt.edu (A. Grace).
Get access

Extract

Under normal circumstances, emotional and affective signals within the brain are tempered by signals from higher brain centres, including the forebrain. These control systems ensure that responses to emotional and affective stimuli are appropriate for the environment within which they are generated. In patients with schizophrenia, these control systems are dysfunctional causing the patients to become oversensitive to such emotional stimuli and leading to the exaggerated reactions that are symptomatic of the disease [7,19].

Type
Research Article
Information
European Psychiatry , Volume 18 , Issue S2: Schizophrenia: Improving the treatment through increased understanding - Mind Matters 4th International Psychiatry Forum , December 2003 , pp. 27s - 31s
Copyright
Copyright © 2003 European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Csernansky, JG, Bardgett, ME. Limbic-cortical neuronal damage and the pathophysiology of schizophrenia Schizophr Bull 1998; 24(2): 231–48.CrossRefGoogle ScholarPubMed
Cullen, TJ, Walker, MA, Parkinson, N., Craven, R, Crow, TJ, Esiri, MMet al. A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia. Schizophr Res 2003; 60(2/3): 157–66.CrossRefGoogle Scholar
Davidson, RJ.Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 2002; 51(1): 68–80.CrossRefGoogle ScholarPubMed
Gallagher, M, Chiba, AA. The amygdala and emotion. Curr Opin Neurobiol 1996, 6(2): 221–7.CrossRefGoogle ScholarPubMed
Garrís, PA, Ciolkowski, EL, Pastore, P, Wightman, RM. Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain. J Neurosci 1994; 14(10): 6084–93.CrossRefGoogle ScholarPubMed
Gothelf, D, Soreni, N, Nachman, RP, Tyano, S, Hiss, Y, Reiner, Oet al. Evidence for the involvement of the hippocampus in the pathophysiology of schizophrenia. Eur Neuropsychopharmacol 2000; 10(5): 389–95.CrossRefGoogle ScholarPubMed
Grace, AA.Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 1991, 41(1): 1–24.CrossRefGoogle ScholarPubMed
Grace, AA.Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Res Rev 2000; 31(2/3)' 330–41.CrossRefGoogle ScholarPubMed
Grace, AA, Onn, SP. Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J Neurosci 1989; 9(10): 3463–81.CrossRefGoogle ScholarPubMed
Groenewegen, HJ, Wright, CI, Beijer, AV. The nucleus accumbens: gateway for limbic structures to reach the motor system? Prog Brain Res 1996; 107:485–511.CrossRefGoogle ScholarPubMed
Kegeles, LS, Abi-Dargham, A, van Dyck, C, Gil, R D'Souza CD, Erdos, Jet al. Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry 2000; 48(7): 627-40.CrossRefGoogle Scholar
Kretschmer, BD.Functional aspects of the ventral pallidum. Amino Acids 2000; 19(1): 201–10.CrossRefGoogle ScholarPubMed
Lamelle, M, Abi-Dargham, A, van Dyck, C, Gil, R, D'Souza, CD, Erdos, Jet al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 1996; 93(17): 9235-40.Google Scholar
Lewis, DA, Melchitzky, DS, Burgos, GG. Specificity in the functional architecture of primate prefrontal cortex. J Neurocytol 2002; 31(3/5): 265–76.CrossRefGoogle ScholarPubMed
Liddle, PF, Friston, KJ, Frith, CD, Hirsch, JR, Jones, T, Frackowiah, RS. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 1992; 160: 179–86.CrossRefGoogle Scholar
Marek, K, Jennings, D, Seybyl, J.Do dopamine agonists or levodopa modify Parkinson's disease progression? Eur J Neurol 2002; 9(3): 15–22.CrossRefGoogle ScholarPubMed
Miller, EK, Freedman, DJ, Wallis, JD. The prefrontal cortex: categories, concepts and cognition. Philos Trans R Soc Lond B Biol Sci 2002; 357(1424): 1123–36.CrossRefGoogle ScholarPubMed
Moore, H, West, AR, Grace, A A. The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol Psychiatry 1999; 46(1): 40–55CrossRefGoogle ScholarPubMed
O'Donnell, P, Grace, AA. Synaptic interactions among excitatory afférents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input. J Neurosci 1995; 15(5 Pt 1): 3622–39.CrossRefGoogle ScholarPubMed
O'Donnell, P, Grace, AA. Dysfunctions in multiple interrelated systems as the neurobiological bases of schizophrenic symptom clusters Schizophr Bull 1998; 24(2): 267–83.CrossRefGoogle ScholarPubMed
Pani, L.Clinical implications of dopamine research in schizophrenia. Curr Med Res Opin 2002; 18(3): S3-S7.CrossRefGoogle Scholar
Parsons, LH, Justice, JB Jr. Extracellular concentration and in vivo recovery of dopamine in the nucleus accumbens using microdialysis. J Neurochem 1992; 58(1): 212–8.CrossRefGoogle ScholarPubMed
Raine, A, Lencz, T, Reynolds, GP, Harrisson, G, Sheard, C, Medley, Iet al. An evaluation of structural and functional prefrontal deficits in schizophrenia: MRI and neuropsychological measures. Psychiatry Res 1992; 45(2): 123–37.CrossRefGoogle ScholarPubMed
Rosenkranz, JA, Grace, AA. Cellular mechanisms of lnfrahmbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo. J Neurosci 2002; 22(1): 324–37.CrossRefGoogle ScholarPubMed
Seeman, P.Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1987; 1(2): 133–52.CrossRefGoogle ScholarPubMed
Sesack, SR, Carr, DB. Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiol Behav 2002, 77(4/5): 513–7.CrossRefGoogle Scholar
Setlow, B.The nucleus accumbens and learning and memory. J Neurosci Res 1997; 49(5): 515–21.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Snyder, SH.Amphetamine psychosis: a 'model'schizophrenia mediated by catecholamines Am J Psychiatry 1973, 130(1): 61–7.CrossRefGoogle ScholarPubMed
Ujike, H.Stimulant-induced psychosis and schizophrenia: the role of sensitization. Curr Psychiatry Rep 2002; 4(3): 177–84.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.