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Efficacy of clozapine in treatment-resistant psychosis and neuroleptic sensitivity: results of the Dutch open multi-center project

Published online by Cambridge University Press:  16 April 2020

WMA Verhoeven ,
WH Doesburg ,
R Snoej ,
AJMP Rutgers  and
PHM van Dongen
WMA Verhoeven
Affiliation:
Vincent van Gogh Institute for Psychiatry, Department of Biological Psychiatry, Stationsweg 46, 5803 AC, Venray
WH Doesburg
Affiliation:
Department of Medical Statistics, University Nijmegen Kapittelweg 54, 6525EP, Nijmegen
R Snoej
Affiliation:
Vincent van Gogh Institute for Psychiatry, Department of Biological Psychiatry, Stationsweg 46, 5803 AC, Venray
AJMP Rutgers
Affiliation:
Psychiatric Hospital Vogelenzang, Rijksstraatweg 113, 2125AD, Bennebroek
PHM van Dongen
Affiliation:
Psychiatric Hospital Coudewater, Berlicumseweg 8, 5248NT, Rosmalen, The Netherlands
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Summary

In an open multi-center study, 57 schizophrenic patients were treated with clozapine for indications of treatment-resistant psychosis or severe extrapyramidal side-effects caused by conventional neuroleptics. In 58% of the patients a clinical relevant improvement, expressed as percentage reduction of at least 50 from baseline BPRS scores was observed. With respect to extrapyramidal side-effects, a marked reduction was found upon treatment with clozapine. No major side-effects occurred, particularly agranulocytosis. It was concluded that clozapine is a potent antipsychotic agent that can be used safely when treatment is accompanied by frequent clinical and hematological monitoring.

Keywords

clozapineschizophreniatreatment-resistant psychosis
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 2 , 1992 , pp. 77 - 84
Copyright
Copyright © Elsevier, Paris 1992

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