Hostname: page-component-7479d7b7d-qs9v7 Total loading time: 0 Render date: 2024-07-11T20:27:41.425Z Has data issue: false hasContentIssue false

923 – Safe Administration Of Clozapine In Hospitalized Psychiatric Patients

Published online by Cambridge University Press:  15 April 2020

D. Begic
Affiliation:
Psychiatric Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina
S. Bise
Affiliation:
Psychiatric Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina
B. Kurtovic
Affiliation:
Psychiatric Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina
O. Cemalovic
Affiliation:
Psychiatric Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina
M. Ahmic
Affiliation:
Psychiatric Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Clozapine is indicated for the management of severely ill schizophrenic patients

who fail to respond adequately to standard drug treatment for schizophrenia. Agranulocytosis is a life-threatening adverse effect which can occur during administration of clozapine, and frequency estimation is between 0,5 and 2 % of patients. This research was conducted in 136 patients treated with Clozapine, from a total number of 528 patients hospitalized in the Psychiatric Hospital of Sarajevo in one year period. Fifty patients (36,26%) from total were females, and 86 patients (63,74%) were male. Average age was 43,43 years, hospitalized approximately 4,55 times in this hospital, they were treated with Clozapine in mono- or combined therapy with middle dosage of 162,32 mg per day. In most of the cases (68,75%) concomitant therapy was associated to Haloperidole.

According to recommendations of manufacturers and algorithms, laboratory blood monitoring and differential blood monitoring were performed.

In this trial there were no cases what so ever that would include differation of total White Blood Cells number or granulocytes of patients hospitalized and treated with Clozapine in one year period.

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2013
Submit a response

Comments

No Comments have been published for this article.