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747 – Brain-Derived Neurotrophic Factor and B-Cell Lymphoma Leukemia-2 Plasma Levels in Patients with Subsyndromal Symptomatic Depression

Published online by Cambridge University Press:  15 April 2020

Z. Li  and
Y. Fang
Z. Li
Affiliation:
Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Y. Fang
Affiliation:
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

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Objective:

To explore the relationship between brain-derived neurotrophic factor (BDNF) and B-cell lymphoma Leukemia-2 (Bcl-2) plasma levels in subsyndromal symptomatic depression (SSD) patients.

Methods:

In this case-control study, Enzyme-Linked Immunosorbnent Assay (ELISA) method was used to analysed the differences of BDNF plasma levels between SSD group (n=42) and healthy controls (n=51). At the same time Hamilton Depression Rating Scale-17(HAMD17) were assessed the patients'severity.

Result:

There were significant difference of BDNF plasma levels between SSD group (medium 2.97 ng/ml)and healthy group (medium 3.71ng/ml, z=-2.94, P 0.003). Furthermore, BDNF plasma levels in SSD patients were associated with Hamilton score (r -0.53, P < 0.001). Plasma Bcl-2 levels were not different between SSD group (medium 4951 U/ml) and health controls (medium 5574 U/ml) (z = -1.71, P =0.09); and plasma Bcl-2 levels in SSD group were not associated with Hamilton score (r -0.10, P 0.34).

Conclusion:

The study suggested that the decreased BDNF plasma levels were related with the pathophysiology of SSD and it might reflect the severity of disorder.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E246
Copyright
Copyright © European Psychiatric Association 2013
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