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2144 – IL-2, IL-6, IFN-gamma And Tgf-beta Genetic Polymorphism With Respect To Susceptibility To Schizophrenia

Published online by Cambridge University Press:  15 April 2020

D. Frydecka
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
A. Beszlej
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
L. Karabon
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland Department and Clinic of Urology, Wroclaw Medical University, Wroclaw, Poland
E. Pawlak-Adamska
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland
A. Tomkiewicz
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland
A. Partyka
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland
B. Misiak
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
P. Piotrowski
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
M. Zagdanska
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
A. Kiejna
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland

Abstract

Background

Schizophrenia is a chronic severe psychiatric disorder with multiple environmental and genetic determinants. Several reports indicate the possible role of immune system dysregulation in the pathogenesis of schizophrenia. An accumulating body of evidence indicates an association of schizophrenia and its psychopathology with altered cytokine production. The variation of the level of cytokines might be partly due to their functional gene polymorphism.

Purpose

The study was carried out to investigate the association of schizophrenia with the following cytokine polymorphisms: IL-2 (-330T/G), IL-6 (-174G/C), IFN-gamma (+874 T/A), TGF-beta (+869 T/C and +915 G/C).

Material and methods

We included 130 patients diagnosed with schizophrenia and 184 controls in our study. The patients were evaluated for lifetime psychotic symptomatology using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. The patients having history of traumatic brain injury, neurologic disorders, substance abuse or immune related diseases were excluded from the study by detailed medical examination.

Results

The polymorphisms were in HWE both in the cases’ and controls’ groups. In single marker analysis, we did not find an association for the tested polymorphisms.

Conclusion

Our data do not support the role of IL-2, IL-6, IFN-gamma and TGF-beta gene polymorphisms in the predisposition to schizophrenia in the Polish population.

Type
Research Article
Copyright
Copyright © European Psychiatric Association 2012
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2144 – IL-2, IL-6, IFN-gamma And Tgf-beta Genetic Polymorphism With Respect To Susceptibility To Schizophrenia
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