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1959 – Neuregulin-1 Gene Polymorphism With Respect To Cognitive Functioning In Schizophrenia

Published online by Cambridge University Press:  15 April 2020

D. Frydecka ,
A. Beszlej ,
P.M. Czerski ,
P. Kapelski ,
L. Karabon ,
A. Kiejna ,
B. Misiak ,
E. Pawlak-Adamska ,
M. Zagdanska  and
J. Hauser
D. Frydecka
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw
A. Beszlej
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw
P.M. Czerski
Affiliation:
Department of Psychiatry, Poznan University of Medical Sciences, Poznan
P. Kapelski
Affiliation:
Department of Psychiatry, Poznan University of Medical Sciences, Poznan
L. Karabon
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland Department and Clinic of Urology, Wroclaw Medical University, Wroclaw, Poland
A. Kiejna
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw
B. Misiak
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw
E. Pawlak-Adamska
Affiliation:
Department of Experimental Therapy, Institute of Immunology and Experimental, Laboratory of Immunopathology, Polish Academy of Sciences, Wroclaw, Poland
M. Zagdanska
Affiliation:
Department of Psychiatry, Wroclaw Medical University, Wroclaw
J. Hauser
Affiliation:
Department of Psychiatry, Poznan University of Medical Sciences, Poznan

Abstract

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Background

Neuregulin-1 (NRG1) may be an important factor in pathogenesis of schizophrenia due to its role in neurodevelopmental processes: myelination, neurotransmitter receptor expression and synaptic plasticity. NRG1 has been also implied to play role in cognitive impairments, which are considered to be endophenotypes of schizophrenia, i.e. subclinical, heritable and independent of clinical state traits associated with genetic susceptibility. Surprisingly, a recent meta-analysis (Dickinson, 2007) demonstrated that reliable and easy to administer Digit Symbol Coding Task (DSCT) discriminate people with schizophrenia from comparison individuals better than the more widely studied neuropsychological instruments.

Purpose

The study was carried out to investigate the association of a polymorphisms of the NRG1 gene (rs62510682) and schizophrenia with respect to performance on DSCT.

Material and methods

We included 103 patients diagnosed with schizophrenia according to ICD-10 criteria and 578 controls in our study. The patients were evaluated for lifetime psychotic symptomatology using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DSCT was administered to 80 patients.

Results

The polymorphisms were in HWE both in the cases’ and controls’ groups. In single marker analysis, we did not find an association for the SNP tested. However; we have found that T allel carriers (TT and/or GT genotype) performed worse than G allel carriers (p=0.4) suggesting weaker cognitive processing efficiency.

Conclusion

Our data do not support the role of the NRG1 gene polymorphism (rs62510682) in the predisposition to schizophrenia; however, the studied SNP might be considered to be a risk factor for cognitive impairment in schizophrenia.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1187
Copyright
Copyright © European Psychiatric Association 2013
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