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1889 – Molecular Genetic Study Of Schizophrenia

Published online by Cambridge University Press:  15 April 2020

J. Barylnik ,
E. Kolesnichenko ,
J. Abrosimova ,
S. Pakhomova ,
V. Borodulin  and
D. Samoilova
J. Barylnik
Affiliation:
Saratov State Medical University, Saratov, Russia
E. Kolesnichenko
Affiliation:
Saratov State Medical University, Saratov, Russia
J. Abrosimova
Affiliation:
Saratov State Medical University, Saratov, Russia
S. Pakhomova
Affiliation:
Saratov State Medical University, Saratov, Russia
V. Borodulin
Affiliation:
Saratov State Medical University, Saratov, Russia
D. Samoilova
Affiliation:
Saratov State Medical University, Saratov, Russia

Abstract

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The genetic determinism with such mental illnesses as schizophrenia has been insufficiently studied.

The aim of our study was to analyze the association of Val66Met polymorphism (Val allele and Met) for the brain-derived neurotrophic factor gene (BDNF gene) with the efficiency of therapy in patients with schizophrenia.

Were examined 142 patients with paranoid schizophrenia. All patients received different versions of antipsychotic pharmacotherapy.

Was found that the presence of Met allele genotype for the studied BDNF gene polymorphism determines a tendency to a more malignant clinical course with resistance to antipsychotic treatment in patients with paranoid schizophrenia. The results of molecular genetic analysis of schizophrenia will lead to better treatment this disorder and may be used in medical and genetic counseling.

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Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1131
Copyright
Copyright © European Psychiatric Association 2013
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