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A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development

  • Robert-Paul Juster (a1) (a2), Gustav Bizik (a3), Martin Picard (a2), Genevieve Arsenault-Lapierre (a1) (a2), Shireen Sindi (a1) (a2), Lyane Trepanier (a1), Marie-France Marin (a1), Nathalie Wan (a1), Zoran Sekerovic (a1), Catherine Lord (a1), Alexandra J. Fiocco (a4), Pierrich Plusquellec (a1) (a5), Bruce S. McEwen (a6) and Sonia J. Lupien (a1)...


The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health.


Corresponding author

Address correspondence and reprint requests to: Robert-Paul Juster, 7401 Hochelaga, McGill University, Louis Riel Pavilion, Unit 226, Room RI-2678, Montreal, QC H1N 3M5, Canada; E-mail:


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