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Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

  • Edward D. Barker (a1), Charlotte A. M. Cecil (a1), Esther Walton (a2), Lotte C. Houtepen (a2), Thomas G. O'Connor (a3), Andrea Danese (a1), Sara R. Jaffee (a4), Sarah K. G. Jensen (a5), Carmine Pariante (a1), Wendy McArdle (a2), Tom R. Gaunt (a2), Caroline L. Relton (a2) and Susanna Roberts (a1)...


In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.

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Corresponding author

Address correspondence and reprint requests to: Edward D. Barker, Department of Psychology, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF UK; E-mail:


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We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. With regard to the ALSPAC DNA methylation, we thank all involved, particularly the laboratory scientists and bioinformaticians who contributed considerable time and expertise to the data in this paper. The UK Medical Research Council and the Wellcome Trust (Grant102215/2/13/2) and the University of Bristol provide core support for ALSPAC. ARIES was funded by BBSRC Grants BBI025751/1 and BB/I025263/1. ARIES is maintained under the auspices of the MRC Integrative Epidemiology Unit at the University of Bristol (MC_UU_12013/2 and MC_UU_12013/8). This research was specifically supported by National Institute of Child and Human Development Grant R01HD068437 (to E.D.B.), Economic and Social Research Council Grants ES/R005516/1 (to E.D.B.) and ES/N001273/1 (to C.C.), and ESRC/BBSRC Grant ES/N000382/1 (to L.C.H.) for the Interpreting epigenetic signatures in studies of early life adversity project (Interstela Project).



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Andersson, N. W., Li, Q., Mills, C. W., Ly, J., Nomura, Y., & Chen, J. (2016). Influence of prenatal maternal stress on umbilical cord blood cytokine levels. Archives of Women's Mental Health, 19, 761767.
Babri, S., Doosti, M.-H., & Salari, A.-A. (2014). Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain, Behavior, and Immunity, 37, 164176.
Baldwin, J. R., Arseneault, L., Caspi, A., Fisher, H. L., Moffitt, T. E., Odgers, C. L., … Kepa, A. (2017). Childhood victimization and inflammation in young adulthood: A genetically sensitive cohort study. Brain, Behavior, and Immunity. Advance online publication.
Barker, E. D., Cecil, C. A. M., Walton, E., Jaffee, S. R., Rowe, R., Maughan, B., … Gaunt, T. R. (in press). A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder. Child Development. doi:10.1111/cdev.12957
Barker, E. D., Kirkham, K., Ng, J., & Jensen, S. M. K. (2013). Prenatal maternal depression, prenatal nutrion and child congitive function. British Journal of Psychiatry, 203, 417421.
Barker, E. D., Seguin, J. R., White, H. R., Bates, M. E., Lacourse, E., Carbonneau, R., & Tremblay, R. E. (2007). Developmental trajectories of male physical violence and theft: Relations to neurocognitive performance. Archives of General Psychiatry, 64, 592599. doi:10.1001/archpsyc.64.5.592
Barker, E. D., Walton, E., & Cecil, C. A. M. (in press). Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology. Journal of Child Psychology and Psychiatry. doi:10.1111/jcpp.12782
Bentler, P. M., & Bonett, D. G. (1980). Significance tests and goodness of fit in the analysis of covariance structures. Psychological Bulletin, 88, 588606.
Binder, A. M., & Michels, K. B. (2013). The causal effect of red blood cell folate on genome-wide methylation in cord blood: A Mendelian randomization approach. BMC Bioinformatics, 14, 1.
Boyd, A., Golding, J., Macleod, J., Lawlor, D. A., Fraser, A., Henderson, J., … Davey Smith, G. (2013). Cohort Profile: The “Children of the 90s”—The index offspring of the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology, 42, 111127. doi:10.1093/ije/dys064
Breuss, M., Heng, J. I.-T., Poirier, K., Tian, G., Jaglin, X. H., Qu, Z., … Haas, M. (2012). Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell Reports, 2, 15541562.
Brown, T. A. (2014). Confirmatory factor analysis for applied research. New York: Guilford Press.
Browne, M. W., & Cudeck, R. (1993). Alternative ways of assessing model fit. In Bollen, K. A. & Long, J. S. (Eds.), Testing structural equation models (pp. 136162). Newburry Park, CA: Sage.
Cecil, C. A. M., Jaffee, S. R., O'Connor, T. G., Oullet-Morin, I., Smith, R., Relton, C. L., … Barker, E. D. (in press). Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study. Development and Psychopathology.
Cecil, C. A. M., Lysenko, L., Jaffee, S. R., Relton, C. L., Mill, J., & Barker, E. D. (2014). Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study. Molecular Psychiatry, 19, 10711077. doi:10.1038/mp.2014.95
Cecil, C. A. M., Smith, R. G., Walton, E., Mill, J., McCrory, E. J., & Viding, E. (2016). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability assessment. Journal of Psychiatric Research, 83, 184194. doi:10.1016/j.jpsychires.2016.09.010
Chen, Y.-A., Lemire, M., Choufani, S., Butcher, D. T., Grafodatskaya, D., Zanke, B. W., … Weksberg, R. (2013). Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics, 8, 203209.
Cicchetti, D., & Rogosch, F. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597600.
Coussons-Read, M. E., Okun, M. L., & Nettles, C. D. (2007). Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain, Behavior, and Immunity, 21, 343350.
Danese, A., & Baldwin, J. R. (2017). Hidden wounds? Inflammatory links between childhood trauma and psychopathology. Annual Review of Psychology, 68, 517544.
Danese, A., Caspi, A., Williams, B., Ambler, A., Sugden, K., Mika, J., … Moffitt, T. (2011). Biological embedding of stress through inflammation processes in childhood. Molecular Psychiatry, 16, 244.
Danese, A., & Lewis, S. J. (2016). Psychoneuroimmunology of early-life stress: The hidden wounds of childhood trauma? Neuropsychopharmacology. Advance online publication.
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., … Caspi, A. (2009). Adverse childhood experiences and adult risk factors for age-related disease: Depression, inflammation, and clustering of metabolic risk markers. Archives of Pediatrics and Adolescent Medicine, 163, 11351143.
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9, 46.
Dehghan, A., Dupuis, J., Barbalic, M., Bis, J. C., Eiriksdottir, G., Lu, C., … Henneman, P. (2011). Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation, 123, 731738.
DeVries, A., Stern, D. A., Wright, A. L., & Vercelli, D. (2017). Neonatal DNA methylation profiles are associated with the maternal prenatal immune milieu selectively in children with non-asthmatic mothers. Paper presented at the American Thoracic Society 2017 International Conference, Washington, DC, May 19–24, 2017.
Ehrlich, K. B., Ross, K. M., Chen, E., & Miller, G. E. (2016). Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? Development and Psychopathology, 28(4, pt. 2), 12731283.
Essex, M. J., Thomas Boyce, W., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M. A., & Kobor, M. S. (2013). Epigenetic vestiges of early developmental adversity: Childhood stress exposure and DNA methylation in adolescence. Child Development, 84, 5875. doi:10.1111/j.1467-8624.2011.01641.x
Fagerberg, L., Hallström, B. M., Oksvold, P., Kampf, C., Djureinovic, D., Odeberg, J., … Edlund, K. (2014). Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Molecular & Cellular Proteomics, 13, 397406.
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016). Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Molecular Psychiatry, 21, 1358.
Frank, M. G., Hershman, S. A., Weber, M. D., Watkins, L. R., & Maier, S. F. (2014). Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology, 40, 191200.
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., … Lawlor, D. A. (2013). Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. International Journal of Epidemiology, 42, 97110. doi:10.1093/ije/dys066
Gaunt, T. R., Shihab, H. A., Hemani, G., Min, J. L., Woodward, G., Lyttleton, O., … Ring, S. M. (2016). Systematic identification of genetic influences on methylation across the human life course. Genome Biology, 17, 61.
Gibbons, D., Fleming, P., Virasami, A., Michel, M.-L., Sebire, N. J., Costeloe, K., … Hayday, A. (2014). Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants. Nature Medicine, 20, 12061210.
Gluckman, P. D., Hanson, M. A., Spencer, H. G., & Bateson, P. (2005). Environmental influences during development and their later consequences for health and disease: Implications for the interpretation of empirical studies. Proceedings of the Royal Society of London B: Biological Sciences, 272, 671677.
Goasdoué, K., Miller, S. M., Colditz, P. B., & Bjorkman, S. T. (2016). The blood-brain barrier: Protecting the developing fetal brain. Placenta. Advance online publication.
Goodman, A., Heiervang, E., Collishaw, S., & Goodman, R. (2011). The “DAWBA bands” as an ordered-categorical measure of child mental health: Description and validation in British and Norwegian samples. Social Psychiatry and Psychiatric Epidemiology, 46, 521532. doi:10.1007/s00127-010-0219-x
Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., … Andersson, M. (2015). Common genetic variants influence human subcortical brain structures. Nature, 520, 224229.
Hostinar, C. E., Nusslock, R., & Miller, G. E. (2017). Future directions in the study of early-life stress and physical and emotional health: Implications of the neuroimmune network hypothesis. Journal of Clinical Child and Adolescent Psychology. Advance online publication.
Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., … Kelsey, K. T. (2012). DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics, 13, 1.
Janusek, L. W., Tell, D., Gaylord-Harden, N., & Mathews, H. L. (2017). Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: An epigenetic link. Brain, Behavior, and Immunity, 60, 126135.
Jensen, S. K., Berens, A. E., & Nelson, C. A. III. (2017). Effects of poverty on interacting biological systems underlying child development. Lancet Child & Adolescent Health. Advance online publication.
Jensen, S. K., Dumontheil, I., & Barker, E. D. (2014). Developmental inter-relations between early maternal depression, contextual risks, and interpersonal stress, and their effect on later child cognitive functioning. Depression and Anxiety, 31, 599607.
Jiang, N. M., Tofail, F., Ma, J. Z., Haque, R., Kirkpatrick, B., Nelson, C. A. III, & Petri, W. A. Jr. (2017). Early life inflammation and neurodevelopmental outcome in Bangladeshi infants growing up in adversity. American Journal of Tropical Medicine and Hygiene, 97, 974979.
Joram, N., Boscher, C., Denizot, S., Loubersac, V., Winer, N., Roze, J., & Gras-Le Guen, C. (2006). Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection. Archives of Disease in Childhood—Fetal and Neonatal Edition, 91, F65F66.
Kaukola, T., Herva, R., Perhomaa, M., Pääkkö, E., Kingsmore, S., Vainionpää, L., & Hallman, M. (2006). Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants. Pediatric Research, 59, 478483.
Khandaker, G. M., Pearson, R. M., Zammit, S., Lewis, G., & Jones, P. B. (2014). Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: A population-based longitudinal study. JAMA Psychiatry, 71, 11211128.
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., … Prinssen, E. P. (2014). Maternal immune activation and abnormal brain development across CNS disorders. Nature Reviews Neurology, 10, 643660.
Lee, H.-S., Barraza-Villarreal, A., Hernandez-Vargas, H., Sly, P. D., Biessy, C., Ramakrishnan, U., … Herceg, Z. (2013). Modulation of DNA methylation states and infant immune system by dietary supplementation with ω−3 PUFA during pregnancy in an intervention study. American Journal of Clinical Nutrition, 98, 480487.
Ligthart, S., Marzi, C., Aslibekyan, S., Mendelson, M. M., Conneely, K. N., Tanaka, T., … Guan, W. (2016). DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biology, 17, 255.
Loeber, R., Menting, B., Lynam, D. R., Moffitt, T. E., Stouthamer-Loeber, M., Stallings, R., … Pardini, D. (2012). Findings from the Pittsburgh Youth Study: Cognitive impulsivity and intelligence as predictors of the age–crime curve. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 11361149.
McDade, T. W., Metzger, M. W., Chyu, L., Duncan, G. J., Garfield, C., & Adam, E. K. (2014). Long-term effects of birth weight and breastfeeding duration on inflammation in early adulthood. Proceedings of the Royal Society Part B: Biological Sciences, 281, 20133116.
McDade, T. W., Ryan, C., Jones, M. J., MacIsaac, J. L., Morin, A. M., Meyer, J. M., … Kuzawa, C. W. (2017). Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood. Proceedings of the National Academy of Sciences, 114, 76117616.
Miller, G. E., & Chen, E. (2013). The biological residue of childhood poverty. Child Development Perspectives, 7, 6773.
Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959.
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002). Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychology, 21, 531.
Mitchell, U. A., & Aneshensel, C. S. (2017). Social inequalities in inflammation: Age variations in older persons. Journal of Aging and Health, 29, 769787.
Monk, C., Feng, T., Lee, S., Krupska, I., Champagne, F. A., & Tycko, B. (2016). Distress during pregnancy: Epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior. American Journal of Psychiatry, 173, 705713.
Muthén, L. K., & Muthén, B. O. (1998–2013). Mplus: Statistical analyses with latent variables. User's guide (6th ed.). Los Angeles: Author.
Muthén, L. K., & Muthén, B. O. (1998–2016). Mplus: The comprehensive modeling program for applied researchers. User's guide (Version 7.22). Los Angeles: Author.
Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium. (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18, 199209.
Nusslock, R., & Miller, G. E. (2016). Early-life adversity and physical and emotional health across the lifespan: A neuroimmune network hypothesis. Biological Psychiatry, 80, 2332.
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3, 97106.
O'Connor, T. G., Moynihan, J. A., & Caserta, M. T. (2014). Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children—Developmental psychoneuroimmunology. Journal of Child Psychology and Psychiatry, 55, 615631.
Pankow, J. S., Folsom, A. R., Cushman, M., Borecki, I. B., Hopkins, P. N., Eckfeldt, J. H., & Tracy, R. P. (2001). Familial and genetic determinants of systemic markers of inflammation: The NHLBI family heart study. Atherosclerosis, 154, 681689.
Patrick, P. D., Oriá, R. B., Madhavan, V., Pinkerton, R. C., Lorntz, B., Lima, A. A., & Guerrant, R. L. (2005). Limitations in verbal fluency following heavy burdens of early childhood diarrhea in Brazilian shantytown children. Child Neuropsychology, 11, 233244.
Price, E. M., Cotton, A. M., Lam, L. L., Farré, P., Emberly, E., Brown, C. J., … Kobor, M. S. (2013). Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array. Epigenetics & Chromatin, 6, 1.
Provençal, N., Suderman, M. J., Guillemin, C., Vitaro, F., Côté, S. M., Hallett, M., … Szyf, M. (2014). Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells. PLOS ONE, 9, e89839.
Relton, C. L., Gaunt, T., McArdle, W., Ho, K., Duggirala, A., Shihab, H., … Reik, W. (2015). Data resource profile: accessible resource for integrated epigenomic studies (ARIES). International Journal of Epidemiology, 44, 11811190.
Richmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., Lyttleton, O., McArdle, W. L., … Tilling, K. (2015). Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Human Molecular Genetics, 24, 22012217.
Rijlaarsdam, J., Cecil, C. A., Walton, E., Mesirow, M. S., Relton, C. L., Gaunt, T. R., … Barker, E. D. (2017). Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems. Journal of Child Psychology and Psychiatry, 58, 1927.
Rock, P., Roiser, J., Riedel, W., & Blackwell, A. (2014). Cognitive impairment in depression: A systematic review and meta-analysis. Psychological Medicine, 44, 20292040.
Schlinzig, T., Johansson, S., Gunnar, A., Ekström, T., & Norman, M. (2009). Epigenetic modulation at birth–altered DNA-methylation in white blood cells after Caesarean section. Acta Paediatrica, 98, 10961099.
Scult, M. A., Paulli, A. R., Mazure, E. S., Moffitt, T. E., Hariri, A. R., & Strauman, T. J. (2017). The association between cognitive function and subsequent depression: A systematic review and meta-analysis. Psychological Medicine, 47, 117.
Séguin, J. R., Nagin, D. S., Assaad, J.-M., & Tremblay, R. E. (2004). Cognitive-neuropsychological function in chronic physical aggression and hyperactivity. Journal of Abnormal Psychology, 113, 603613.
Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., … Mendelson, M. M. (2015). Improving phenotypic prediction by combining genetic and epigenetic associations. American Journal of Human Genetics, 97, 7585.
Sureshchandra, S., Wilson, R. M., Rais, M., Marshall, N. E., Purnell, J. Q., Thornburg, K. L., & Messaoudi, I. (2017). Maternal pregravid obesity remodels the DNA methylation landscape of cord blood monocytes disrupting their inflammatory program. Journal of Immunology. Advance online publication.
Tilley, S. K., Joseph, R. M., Kuban, K. C., Dammann, O. U., O'Shea, T. M., & Fry, R. C. (2017). Genomic biomarkers of prenatal intrauterine inflammation in umbilical cord tissue predict later life neurological outcomes. PLOS ONE, 12, e0176953.
Tzoulaki, I., Jarvelin, M.-R., Hartikainen, A.-L., Leinonen, M., Pouta, A., Paldanius, M., … Saikku, P. (2008). Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 Birth Cohort study. European Heart Journal, 29, 10491056.
van Otterdijk, S. D., Binder, A. M., & Michels, K. B. (in press). Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy. Epigenetics.
Wadhwa, P. D., Buss, C., Entringer, S., & Swanson, J. M. (2009). Developmental origins of health and disease: Brief history of the approach and current focus on epigenetic mechanisms. Seminars in Reproductive Medicine, 27, 358368.
Weschsler, D., Golombok, S., & Rust, J. (1992). WISC-III UK: Wechsler Intelligence Scale for Children. Sidcup, UK: Psychological Corporation.
Yoon, B. H., Romero, R., Park, J. S., Kim, M., Oh, S.-Y., Kim, C. J., & Jun, J. K. (2000). The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. American Journal of Obstetrics and Gynecology, 183, 11241129.
Zhang, Y., Collier, F., Naselli, G., Saffery, R., Tang, M. L., Allen, K. J., … Vuillermin, P. (2016). Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “TH2-type” immunity associated with development of food allergy. Science Translational Medicine, 8, 321ra328321ra328.

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Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

  • Edward D. Barker (a1), Charlotte A. M. Cecil (a1), Esther Walton (a2), Lotte C. Houtepen (a2), Thomas G. O'Connor (a3), Andrea Danese (a1), Sara R. Jaffee (a4), Sarah K. G. Jensen (a5), Carmine Pariante (a1), Wendy McArdle (a2), Tom R. Gaunt (a2), Caroline L. Relton (a2) and Susanna Roberts (a1)...


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