Skip to main content Accessibility help

Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective

  • Theodore P. Beauchaine (a1) and Dante Cicchetti (a2) (a3)
  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective
      Available formats

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective
      Available formats

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective
      Available formats


  • An abstract is not available for this content so a preview has been provided below. To view the full text please use the links above to select your preferred format.


Corresponding author

Author for Correspondence: Theodore P. Beauchaine, Department of Psychology, Ohio State University, 1835 Neil Avenue, Columbus, OH 43210; E-mail:


Hide All
Adrian, M., Zeman, J., & Veits, G. (2011). Methodological implications of the affect revolution: A 35-year review of emotion regulation assessment in children. Journal of Experimental Child Psychology, 110, 171197. doi:10.1016=j.jecp.2011.03.009
Aldao, A. (2013). The future of emotion regulation research: Capturing context. Perspectives on Psychological Science, 8, 155172. doi:10.1177/1745691612459518
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author.
Arnsten, A. F. T., & Rubia, K. (2012). Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: Disruptions in neurodevelopmental psychiatric disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 356367. doi:10.1016/j.jaac.2012.01.008
Barrett, L. F. (2009). The future of psychology: Connecting mind to brain. Perspectives on Psychological Science, 4, 326339. doi:10.1111/j.1745-6924.2009.01134.x
Barrett, L. F. (2017). Functionalism cannot save the classical view of emotion. Social Cognitive and Affective Neuroscience, 12, 3436. doi:10.1093/scan/nsw156
Barrett, L. F., & Satpute, A. (2013). Large-scale brain networks in affective and social neuroscience: Towards an integrative architecture of the human brain. Current Opinion in Neurobiology, 23, 112. doi:10.1016/j.conb.2012.12.012
Barrett, L. F., Wilson-Mendenhall, C. D., & Barsalou, L. W. (2013). A psychological construction account of emotion regulation and dysregulation: The role of situated conceptualizations. In Gross, J. J. (Ed.), Handbook of emotion regulation (2nd ed., pp. 447465). New York: Guilford Press.
Barsalou, L. W. (2016). Situated conceptualization offers a theoretical account of social priming. Current Opinion in Psychology, 12, 611. doi:10.1016/j.copsyc.2016.04.009
Beauchaine, T. P. (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13, 183214. doi:10.1017/S0954579401002012
Beauchaine, T. P. (2015). Future directions in emotion dysregulation and youth psychopathology. Journal of Clinical Child and Adolescent Psychology, 44, 875896. doi:10.1080/15374416.2015.1038827
Beauchaine, T. P., & Constantino, J. N. (2017). Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity. Biomarkers in Medicine, 11, 769780. doi:10.221/bmm-2017-0002
Beauchaine, T. P., Constantino, J. N., & Hayden, E. P. (2018). Psychiatry and developmental psychopathology: Unifying themes and future directions. Comprehensive Psychiatry, 87, 143152. doi:10.1016/j.comppsych.2018.10.014
Beauchaine, T. P., & Haines, N. (2019). Functionalist and constructionist perspectives on emotion dysregulation. In Beauchaine, T. P. & Crowell, S. E. (Eds.), The Oxford handbook of emotion dysregulation. New York: Oxford University Press.
Beauchaine, T. P., Hinshaw, S. P., & Bridge, J. A. (2019). Nonsuicidal self-injury and suicidal behaviors in girls: The case for targeted prevention in preadolescence. Clinical Psychological Science. Advance online publication. doi:10.1177/2167702618818474
Beauchaine, T. P., & Zisner, A. (2017). Motivation, emotion regulation, and the latent structure of psychopathology: An integrative and convergent historical perspective. International Journal of Psychophysiology, 119, 108118. doi:10.1016/j.ijpsycho.2016.12.014
Beauchaine, T. P., Zisner, A. R., & Hayden, E. P. (2019). Neurobiological mechanisms of psychopathology and treatment action. In Ollendick, T. H., White, S. W., & White, B. A. (Eds.), The Oxford handbook of clinical child and adolescent psychology (pp. 699723). New York: Oxford University Press.
Beyeler, A. (2016). Parsing reward from aversion. Science, 354, 558. doi:10.1126/science.aak9762
Bhugra, D., & McKenzie, K. (2003). Expressed emotion across cultures. Advances in Psychiatric Treatment, 9, 342348. doi:10.1192/apt.9.5.342
Bradley, B., DeFife, J. A., Guarnaccia, C., Phifer, J., Fani, N., Ressler, K. J., & Westen, D. (2011). Emotion dysregulation and negative affect: Association with psychiatric symptoms. Journal of Clinical Psychiatry, 72, 685691. doi:10.4088/JCP.10m06409blu
Brain Development Cooperative Group. (2012). Total and regional brain volumes in a population-based normative sample from 4 to 18 years: The NIH MRI study of normal brain development. Cerebral Cortex, 22, 112. doi:10.1093/cercor/bhr018
Campos, J. J., Mumme, D. L., Kermoian, R., & Campos, R. G. (1994). A functionalist perspective on the nature of emotion. Monographs of the Society for Research on Child Development, 59, 284303. doi:10.1111/j.1540-5834.1994.tb01289.x
Carlén, M. (2017). What constitutes the prefrontal cortex? Science, 358, 478482. doi:10.1126/science.aan8868
Casey, B. J., Getz, S., & Galvan, A. (2008). The adolescent brain. Developmental Review, 28, 6277. doi:10.1016/j.dr.2007.08.003
Casey, B. J., Oliveri, M. E., & Insel, T. (2014). A neurodevelopmental perspective on the Research Domain Criteria (RDoC) framework. Biological Psychiatry, 76, 350353. doi:10.1016/j.biopsych.2014.01.006
Churchwell, J. C., Morris, A. M., Heurtelou, N. M., & Kesner, R. P. (2009). Interactions between the prefrontal cortex and amygdala during delay discounting and reversal. Behavioral Neuroscience, 123, 11851196. doi:10.1037/a0017734
Cicchetti, D., Ackerman, B. P., & Izard, C. E. (1995). Emotions and emotion regulation in developmental psychopathology. Development and Psychopathology, 7, 110. doi:10.1017/S0954579400006301
Cicchetti, D., & Thomas, K. M. (2008). Imaging brain systems in normality and psychopathology. Development and Psychopathology, 20, 10231027.
Cole, P. M., Hall, S. E., & Hajal, N. (2017). Emotion dysregulation as a vulnerability to psychopathology. In Beauchaine, T. P. & Hinshaw, S. P. (Eds.), Child and adolescent psychopathology (3rd ed., pp. 346386). Hoboken, NJ: Wiley.
Cole, P. M., Martin, S. E., & Dennis, T. A. (2004). Emotion regulation as a scientific construct: Methodological challenges and directions for child development research. Child Development, 75, 317333. doi:10.1111/j.1467-8624.2004.00673.x
Corr, P. J. (2013). Approach and avoidance behaviour: Multiple systems and their interactions. Emotion Review, 5, 285290. doi:10.1177/1754073913477507
Cubillo, A., Halari, R., Smith, A., Taylor, E., & Rubia, K. (2012). A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with ADHD and new evidence for dysfunction in adults with ADHD during motivation and attention. Cortex, 48, 194215. doi:10.1016/j.cortex.2011.04.007
Davidson, R. J., Jackson, D. C., & Kalin, N. H. (2000). Emotion, plasticity, context, and regulation: Perspectives from affective neuroscience. Psychological Bulletin, 126, 890909. doi:10.1037/0033-2909.126.6.890
Dawson, G. (1994). Frontal electroencephalographic correlates of individual differences in emotion expression in infants: A brain systems perspective on emotion. Monographs of the Society for Research in Child Development, 59, 135151. doi:10.1111/1540-5834.ep9502132768
De Brito, S. A., Mechelli, A., Wilke, M., Laurens, K. R., Jones, A. P., Barker, G. J., … Viding, E. (2009). Size matters: Increased grey matter in boys with conduct problems and callous–unemotional traits. Brain, 132, 843852. doi:10.1093/brain/awp011
Dong, X., Li, S., & Kirouac, G. J. (2017). Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala. Brain Structure and Function, 222, 39273943. doi:10.1007/s00429-017-1445-8
Duncan, S., & Barrett, L. F. (2007). Affect is a form of cognition: A neurobiological analysis. Cognition and Emotion, 21, 11841211. doi:10.1080/02699930701437931
Eisenberg, N., Losoya, S., Fabes, R. A., Guthrie, I. K., Reiser, M., Murphy, B., … Padgett, S. J. (2001). Parental socialization of children's dysregulated expression of emotion and externalizing problems. Journal of Family Psychology, 15, 183205. doi:10.1037/0893-3200.15.2.183
Etkin, A., Büchel, C., & Gross, J. J. (2015). The neural bases of emotion regulation. Nature Reviews Neuroscience, 16, 693700. doi:10.1038/nrn4044
Fox, E. (2018). Perspectives from affective science on understanding the nature of emotion. Brain and Neuroscience Advances, 2, 18. doi:10.1177/2398212818812628
Fox, N. A. (Ed.) (1994a). The development of emotion regulation: Biological and behavioral considerations. Monographs of the Society for Research in Child Development, 59, 101136.
Fox, N. A. (1994b). Dynamic cerebral processes underlying emotion regulation. Monographs of the Society for Research in Child Development, 59, 152166. doi:10.1111/j.1540-5834.1994.tb01282.x
Gold, A. L., Shechner, T., Farber, M. J., Spiro, C. N., Leibenluft, E., Pine, D. S., & Britton, J. C. (2016). Amygdala-cortical connectivity: Associations with anxiety, development, and threat. Depression and Anxiety, 33, 917926. doi:10.1002/da.22470
Goldin, P. R., McRae, K., Ramel, W., & Gross, J. J. (2008). The neural bases of emotion regulation: Reappraisal and suppression of negative emotion. Biological Psychiatry, 63, 577586. doi:10.1016/j.biopsych.2007.05.031
Graziano, P., Keane, S. P., & Calkins, S. D. (2010). Maternal behaviour and children's early emotion regulation skills differentially predict development of children's reactive control and later effortful control. Infant and Child Development, 19, 333353. doi:10.1002/icd.670
Gross, J. J., & Jazaieri, H. (2014). Emotion, emotion regulation, and psychopathology: An affective science perspective. Clinical Psychological Science, 2, 387401. doi:10.1177/2167702614536164
Hair, N. L., Hanson, J. L., Wolfe, B. L., & Pollak, S. D. (2015). Association of child poverty, brain development, and academic achievement. JAMA Pediatrics, 169, 822829. doi:10.1001/jamapediatrics.2015.1475
Hanson, J. L., Hair, N., Shen, D. G., Shi, F., Gilmore, J. H., Wolfe, B. L., & Pollak, S. D. (2013). Family poverty affects the rate of human infant brain growth. PLOS ONE, 8, e80954. doi:0.1371/journal.pone.0080954
Hart, J., Gunnar, M., & Cicchetti, D. (1995). Salivary cortisol in maltreated children: Evidence of relations between neuroendocrine activity and social competence. Development and Psychopathology, 7, 1126. doi:10.1017/S0954579400006313
Hauser, T. U., Will, G.-J., Dubois, M., & Dolan, R. J. (2019). Annual Research Review: Developmental computational psychiatry. Journal of Child psychology and Psychiatry. Advance online publication. doi:10.1111/jcpp.12964
Heatherton, T. F. (2011). Neuroscience of self and self-regulation. Annual Review of Psychology, 62, 363390. doi:10.1146/annurev.psych.121208.131616
Hilt, L. M., Hanson, J. L., & Pollak, S. D. (2011). Emotion dysregulation. In Brown, B. B. & Prinstein, M. J. (Eds.), Encyclopedia of adolescence (Vol. 3, pp. 160169). New York: Elsevier.
Hostinar, C. E., & Cicchetti, D. (2019). Emotion dysregulation and internalizing spectrum disorders. In Beauchaine, T. P. & Crowell, S. E. (Eds.), The Oxford handbook of emotion dysregulation. New York: Oxford University Press.
Katz, L. F., & Gottman, J. M. (1995). Vagal tone protects children from marital conflict. Development and Psychopathology, 7, 8892. doi:10.1017/S0954579400006350
Keltner, D., & Gross, J. J. (1999). Functional accounts of emotions. Cognition and Emotion, 13, 467480. doi:10.1080/026999399379140
Korponay, C., Pujara, M., Deming, P., Philippi, C., Decety, J., Kosson, D. S., … Koenigs, M. (2017). Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2, 149157. doi:10.1016/j.bpsc.2016.07.004
Krishnan, S., Watkins, K. E., & Bishop, D. V. M. (2016). Neurobiological basis of language learning difficulties. Trends in Cognitive Sciences, 20, 701714. doi:10.1016/j.tics.2016.06.012
Kujawa, A., Wu, M., Klumpp, H., Pine, D. S., Swain, J. E., Fitzgerald, K. D., … Phan, K. L. (2016). Altered development of amygdala-anterior cingulate cortex connectivity in anxious youth and young adults. Biological Psychiatry Cognition Neuroscience Neuroimaging, 1, 345352. doi:10.1016/j.bpsc.2016.01.006
Leshin, J. C., & Lindquist, K. A. (2019). Neuroimaging of emotion dysregulation. In Beauchaine, T. P. & Crowell, S. E. (Eds.), The Oxford handbook of emotion dysregulation. New York: Oxford University Press.
Macdonald, A., Goines, K., Novacek, E., & Walker, E. (2016). Prefrontal mechanisms of comorbidity from a transdiagnostic and ontogenic perspective Development and Psychopathology, 28, 11471175. doi:10.1017/S0954579416000742
Mauss, I. B., & Butler, E. A. (2010). Cultural context moderates the relationship between emotion control values and cardiovascular challenge versus threat responses. Biological Psychology, 84, 521530. doi:10.1016/j.biopsycho.2009.09.010
McLaughlin, K. A., Hatzenbuehler, M. L., Mennin, D. S., & Nolen-Hoeksema, S. (2011). Emotion dysregulation and adolescent psychopathology: A prospective study. Behavior Research and Therapy, 49, 544554. doi:10.1016/j.brat.2011.06.003
Mead, H. K., Beauchaine, T. P., & Shannon, K. E. (2010). Neurobiological adaptations to violence across development. Development and Psychopathology, 22, 122. doi:10.1017/S0954579409990228
National Institute of Mental Health. (2019). Research Domain Criteria matrix. Retrieved March 25, 2019, from
Nguyen-Louie, T. T., Simmons, A. N., Squeglia, L. M., Alejandra Infante, M., Schacht, J. P., & Tapert, S. F. (2018). Earlier alcohol use onset prospectively predicts changes in functional connectivity. Psychopharmacology, 235, 10411054. doi:10.1007/s00213-017-4821-4
Palacios-Barrios, E. E., & Hanson, J. L. (2019). Poverty and self-regulation: Connecting psychosocial processes, neurobiology, and the risk for psychopathology. Comprehensive Psychiatry, 90, 5264. doi:10.1016/j.comppsych.2018.12.012
Panksepp, J. (2016). The psycho-neurology of cross-species affective/social neuroscience: Understanding animal affective states as a guide to development of novel psychiatric treatments. Current Topics in Behavioral Neuroscience, 30, 109125. doi:10.1007/7854_2016_458
Papa, A., & Epstein, E. (2018). Emotions and emotion regulation. In Hayes, S. C. & Hofmann, S. G. (Eds.), Process-based CBT (pp. 137152). Oakland, CA: New Harbinger.
Pfefferbaum, A., Kwon, D., Brumback, T., Thompson, W. K., Cummins, K., Tapert, S. F., … Sullivan, E. V. (2018). Altered brain developmental trajectories in adolescents after initiating drinking. American Journal of Psychiatry, 175, 370380. doi:10.1176/appi.ajp.2017.17040469
Porges, S. W., Doussard-Roosevelt, J. A., & Maiti, A. K. (1994). Vagal tone and the physiological regulation of emotion. Monographs of the Society for Research on Child Development, 59, 167186. doi:10.1111/1540-5834.ep9502132771
Qing, L., Haoran, L., Luo, G., Wang, Y., Tang, H., Han, L., & Yao, Z. (2012). Impaired prefrontal-amygdala effective connectivity is responsible for the dysfunction of emotion process in major depressive disorder: A dynamic causal modeling study on MEG. Neuroscience Letters, 523, 125130. doi:10.1016/j.neulet.2012.06.058
Ramsook, K. A., Cole, P. M., & Fields-Olivieri, M. A. (2019). What emotion dysregulation looks like: Inferences from behavioral observations. In Beauchaine, T. P. & Crowell, S. E. (Eds.), The Oxford handbook of emotion dysregulation. New York: Oxford University Press.
Rottenberg, J. (2005). Mood and emotion in major depression. Current Directions in Psychological Science, 14, 167170. doi:10.1111/j.0963-7214.2005.00354.x
Russell, J. A., & Barrett, L. F. (1999). Core affect, prototypical emotional episodes, and other things called emotion: Dissecting the elephant. Journal of Personality and Social Psychology, 76, 805819. doi:10.1037/0022-3514.76.5.805
Sauder, C. L., Beauchaine, T. P., Gatzke-Kopp, L. M., Shannon, K. E., & Aylward, E. (2009). Neuroanatomical correlates of heterotypic comorbidity in externalizing male adolescents. Journal of Clinical Child and Adolescent Psychology, 41, 346352. doi:10.1080/15374416.2012.658612
Sauder, C. L., Derbidge, C. M., & Beauchaine, T. P. (2016). Neural responses to monetary incentives among self-injuring adolescent girls. Development and Psychopathology, 28, 277291. doi:10.1017/S0954579415000449
Schultz, W. (2016). Dopamine reward prediction-error signaling: A two-component response. Nature Reviews Neuroscience, 7, 183195. doi:10.1038/nrn.2015.26
Shannon, K. E., Sauder, C., Beauchaine, T. P., & Gatzke-Kopp, L. (2009). Disrupted effective connectivity between the medial frontal cortex and the caudate in adolescent boys with externalizing behavior disorders. Criminal Justice and Behavior, 36, 11411157. doi:10.1177/0093854809342856
Shaw, P., Malek, M., Watson, B., Sharp, W., Evans, A., & Greenstein, D. (2012). Development of cortical surface area and gyrification in ADHD. Biological Psychiatry, 72, 191197. doi:10.1016/j.biopsych.2012.01.031
Sheppes, G., Suri, G., & Gross, J. J. (2015). Emotion regulation and psychopathology. Annual Review of Clinical Psychology, 11, 379405. doi:10.1146/annurev-clinpsy-032814-112739
Stansbury, K., & Gunnar, M. R. (1994). Adrenocortical activity and emotion regulation. Monographs of the Society for Research in Child Development, 59, 108134. doi:10.1111/1540-5834.ep9502132766
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014). Functional organization of the hippocampal longitudinal axis. Nature Reviews Neuroscience, 15, 655669. doi:10.1038/nrn3785
Swartz, J. R., Carrasco, M., Wiggins, J. L., Thomason, M. E., & Monk, C. S. (2014). Age-related changes in the structure and function of prefrontal cortex–amygdala circuitry in children and adolescents: A multi-modal imaging approach. NeuroImage, 86, 212220. doi:10.1016/j.neuroimage.2013.08.018
Thompson, R. A. (1990). Emotion and self-regulation. In Thompson, R. A. (Ed.), Nebraska Symposium on Motivation: Vol. 36. Socioemotional development (pp. 383483). Lincoln, NE: University of Nebraska Press.
Thompson, R. A., & Meyer, S. (2007). Socialization of emotion regulation in the family. In Gross, J. J. (Ed.), Handbook of emotion regulation (pp. 249268). New York: Guilford Press.
Tone, E. B., Garn, C. L., & Pine, D. S. (2016). Anxiety regulation: A developmental psychopathology perspective. In Cicchetti, D. (Ed.), Developmental psychopathology: Vol. 2. Developmental neuroscience (3rd ed., pp. 523556). Hoboken, NJ: Wiley.
Trull, T. J. (2012). The Five-Factor Model of Personality Disorder and DSM-5. Journal of Personality, 80, 16971720. doi:10.1111/j.1467-6494.2012.00771.x
Volkow, N., Wise, R. A., & Baler, R. (2017). The dopamine motive system: Implications for drug and food addiction. Nature Reviews Neuroscience, 18, 741752. doi:10.1038/nrn.2017.130
Web of Science. (2019). Citation report for 2,819 results from Web of Science Core Collection between 1900 and 2019. Retrieved March 24, 2019, from
Zahn-Waxler, C., Cole, P. M., Welsh, J. D., & Fox, N. A. (1995). Psychophysiological correlates of empathy and prosocial behaviors in preschool children with behavior problems. Development and Psychopathology, 7, 2748. doi:10.1017/S0954579400006325
Zelazo, P. D. (2015). Executive function: Reflection, iterative reprocessing, complexity, and the developing brain. Developmental Review, 38, 5568. doi:10.1016/j.dr.2015.07.001
Zilverstand, A., Parvaz, M. A., & Goldstein, R. Z. (2017). Neuroimaging cognitive reappraisal in clinical populations to define neural targets for enhancing emotion regulation. A systematic review. NeuroImage, 151, 105116. doi:10.1016/j.neuroimage.2016.06.009

Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective

  • Theodore P. Beauchaine (a1) and Dante Cicchetti (a2) (a3)


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed