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Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up

Published online by Cambridge University Press:  02 August 2019

Justin D. Smith*
Affiliation:
Center for Prevention Implementation Methodology for Drug Abuse and HIV, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine & Institute for Innovations in Developmental Sciences, Northwestern University
Lauren Wakschlag
Affiliation:
Department of Medical Social Sciences, Feinberg School of Medicine & Institute for Innovations in Developmental Sciences, Northwestern University
Sheila Krogh-Jespersen
Affiliation:
Department of Medical Social Sciences, Feinberg School of Medicine & Institute for Innovations in Developmental Sciences, Northwestern University
John T. Walkup
Affiliation:
Department of Psychiatry and Behavioral Sciences, Division of Child & Adolescent Psychiatry, Feinberg School of Medicine, Institute for Innovations in Developmental Sciences, Northwestern University, & Ann & Robert H. Lurie Children's Hospital
Melvin N. Wilson
Affiliation:
Department of Psychology, University of Virginia
Thomas J. Dishion
Affiliation:
REACH Institute, Department of Psychology, Arizona State University & Oregon Research Institute
Daniel S. Shaw
Affiliation:
Department of Psychology, University of Pittsburgh
*
Author for correspondence: Justin D. Smith, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Drive, Chicago, IL 60611; E-mail: jd.smith@northwestern.edu.

Abstract

Building on prior work using Tom Dishion's Family Check-Up, the current article examined intervention effects on dysregulated irritability in early childhood. Dysregulated irritability, defined as reactive and intense response to frustration, and prolonged angry mood, is an ideal marker of neurodevelopmental vulnerability to later psychopathology because it is a transdiagnostic indicator of decrements in self-regulation that are measurable in the first years of life that have lifelong implications for health and disease. This study is perhaps the first randomized trial to examine the direct effects of an evidence- and family-based intervention, the Family Check-Up (FCU), on irritability in early childhood and the effects of reductions in irritability on later risk of child internalizing and externalizing symptomatology. Data from the geographically and sociodemographically diverse multisite Early Steps randomized prevention trial were used. Path modeling revealed intervention effects on irritability at age 4, which predicted lower externalizing and internalizing symptoms at age 10.5. Results indicate that family-based programs initiated in early childhood can reduce early childhood irritability and later risk for psychopathology. This holds promise for earlier identification and prevention approaches that target transdiagnostic pathways. Implications for future basic and prevention research are discussed.

Type
Special Issue Articles
Copyright
Copyright © Cambridge University Press 2019 

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