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The role of tissue plasminogen activator in the successful treatment of infected cardiac thrombus in children

Published online by Cambridge University Press:  15 August 2006

Eli Zalzstein ,
Nili Zucker  and
Aviva Levitas
Eli Zalzstein
Affiliation:
Pediatric Cardiology Unit, Cardiology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion, University of the Negev, Beer Sheva, Israel
Nili Zucker
Affiliation:
Pediatric Cardiology Unit, Cardiology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion, University of the Negev, Beer Sheva, Israel
Aviva Levitas
Affiliation:
Pediatric Cardiology Unit, Cardiology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion, University of the Negev, Beer Sheva, Israel
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Abstract

Infected cardiac thrombus is rare in children, with antibiotic or antifungal agents used as the first line of treatment. Persistence is an indication for surgical intervention. We describe two children who were treated successfully with a combination of antibiotic and antithrombotic agents. Use of antithrombotic agents promotes degeneration of fibrin, thus reducing the mass and facilitating the diffusion of the antibiotic and/or antifungal agents.

Keywords

Infected cardiac thrombusplasminogen
Type
Brief Report
Information
Cardiology in the Young , Volume 11 , Issue 3 , May 2001 , pp. 355 - 356
Copyright
2001 Cambridge University Press

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