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You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer

Published online by Cambridge University Press:  29 November 2010

Jerry W. Shay
The University of Texas Southwestern Medical Center at Dallas*
Harold Werbin
The University of Texas Southwestern Medical Center at Dallas*
Woodring E. Wright
The University of Texas Southwestern Medical Center at Dallas*


Des mécanismes moléculaires liant le cancer à la sénescence cellulaire sont présentement explorés. Les télomères (l'extrémité des chromosomes) raccourcissent à chaque division cellulaire et il a été proposé que ce raccourcissement soit l'horloge moléculaire qui déclenche le processus de la sénescence cellulaire. La re-expression de la télomérase, une enzyme qui aide à maintenir la longueur des télomères et à prévenir leur raccourcissement, est un événement fréquemment observé dans les cellules tumorales. Cette re-expression est probablement essentielle à la formation et à la croissance soutenue de la majorité des cancers.

Copyright © Canadian Association on Gerontology 1995

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