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Vascular Amyloid in the Aging Central Nervous System: Clinico-Pathological Study and Literature Review

Published online by Cambridge University Press:  18 September 2015

Joseph Bruni ,
Juan M. Bilbao  and
Kenneth P.H. Pritzker
Joseph Bruni
Affiliation:
Departments of Pathology, st. Michael's Hospital, Mount Sinai Hospital and University of Toronto, Toronto, Canada
Juan M. Bilbao
Affiliation:
Departments of Pathology, st. Michael's Hospital, Mount Sinai Hospital and University of Toronto, Toronto, Canada
Kenneth P.H. Pritzker*
Affiliation:
Departments of Pathology, st. Michael's Hospital, Mount Sinai Hospital and University of Toronto, Toronto, Canada
*
Division of Pathology, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
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Summary:

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The clinico-pathological features of five patients with vascular amyloid restricted to the central nervous system are presented.

In three normotensive patients, intracerebral hemorrhage was the dramatic manifestation of amyloid angiopathy. In two other cases, one of amyloid in an arteriovenous malformation, the other of amyloid following therapeutic radiation, amyloid deposition was asymptomatic.

Clinically, amyloid angiopathy must be considered in the different diagnosis of intracerebral hemorrhage, independent of the presence of dementia. Pathologically, a factor common to the syndrome of cerebrovascular amyloid appears to be locally increased vascular permeability resulting from a variety of previous tissue injuries.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 4 , November 1977 , pp. 239 - 244
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

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