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Unique Experiences with Intercontinental Trials in Stroke - Part II

Published online by Cambridge University Press:  23 September 2014

H.J.M. Barnett  and
John (Jack) Coleman Laidlaw
H.J.M. Barnett*
Affiliation:
University of Toronto, Toronto, Ontario, Canada
John (Jack) Coleman Laidlaw
Affiliation:
University of Toronto, Toronto, Ontario, Canada
*
Suite 701, 305 Balliol Street, Toronto, Ontario, M4S 3H5, Canada. Email: hjmb@bell.net
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Abstract:

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Supported by the Canadian Medical Research Council we performed a randomized trial extending from Newfoundland to British Columbia. With others a number of observations showed that aspirin will reduce stroke. With National Institute of Neurological Disorders and Stroke support we learned who would benefit and not from surgery in these stroke threatened carotid diseased patients. We evaluated the upper limits of acceptability of complications beyond which harm was done. Amassing this large data base of approximately 5000 individuals, followed for five years, previously unknown carotid phenomena were observed: 1. Ischemic stroke occurs in patients with prolapsing mitral valves; 2. There is risk of stroke in patients with residual thrombi in the occluded stump of the carotid artery; 3. We detected a lower risk than expected in patients with nearly occluded carotid arteries. We support the contention of Yusuf and Cairns' that Canada needs to give more financial support to purely clinical research. It pays off!

Type
Historical Review
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 5 , September 2013 , pp. 645 - 651
Copyright
Copyright © The Canadian Journal of Neurological 2013

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