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Tremor - Easily Seen but Difficult to Describe and Treat

Published online by Cambridge University Press:  02 December 2014

D.A. Grimes
D.A. Grimes*
Affiliation:
Parkinson's Disease and Movement Disorders Clinic, The Ottawa Hospital, Ottawa, Canada
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Abstract

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Tremor is a common movement disorder yet many physicians struggle with its terminology as well as with its treatment. Attempts have been made to develop standard terminology and criteria for tremors but this process continues to evolve. In this review, a summary of the currently-proposed phenomenology and syndromic classification of all types of tremor is presented. The diagnosis and management of essential tremor is presented in more detail, as it is the most commonly encountered tremor.

Résumé

RÉSUMÉ

Le tremblement est un dérdre du mouvement fréent qui, pour plusieurs mécins, comporte des difficultéterminologiques et thépeutiques. On a tentée délopper une terminologie et des critès standard pour les tremblements, mais ce processus est en constante élution. Dans cette revue, nous préntons un sommaire de la phémélogie actuelle et une classification syndromique de tous les types de tremblement. Comme le tremblement essentiel est le tremblement le plus fréemment rencontréson diagnostic et sa prise en charge sont préntéen déil.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 30 , supplement S1: A Peer-Reviewed Supplement to the Canadian Journal of Neurological Sciences , February 2003 , pp. S59 - S63
Copyright
Copyright © The Canadian Journal of Neurological 2003

References

1. Deuschl, G, Bain, P, Brin, M. Consensus statement of the MovementDisorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord 1998; 13(Suppl 3): 2–23.Google Scholar
2. Britton, TC, Thompson, PD. Primary orthostatic tremor. BMJ 1995;310(6973):143–144.CrossRefGoogle ScholarPubMed
3. Rosenbaum, F, Jankovic, J. Focal task-specific tremor and dystonia: categorization of occupational movement disorders. Neurology 1988; 38(4):522–527.Google Scholar
4. Krack, P, Deuschl, G, Kaps, M, et al. Delayed onset of “rubral tremor” 23 years after brainstem trauma. Mov Disord 1994; 9(2): 240–242.Google Scholar
5. Shepherd, GM, Tauboll, E, Bakke, SJ, Nyberg-Hansen, R. Midbraintremor and hypertrophic olivary degeneration after pontine hemorrhage. Mov Disord 1997; 12(3):432–437.Google Scholar
6. Miwa, H, Hatori, K, Kondo, T, Imai, H, Mizuno, Y. Thalamic tremor: case reports and implications of the tremor-generating mechanism. Neurology 1996; 46(1): 75–79.CrossRefGoogle ScholarPubMed
7. Masucci, EF, Kurtzke, JF, Saini, N. Myorhythmia: a widespreadmovement disorder. Clinicopathological correlations. Brain 1984; 107(Pt 1): 53–79.Google ScholarPubMed
8. Holmes, G. On certain tremors in organic cerebral lesions. Brain 1904(27): 327–375.CrossRefGoogle Scholar
9 Louis, ED, Ford, B, Frucht, S, et al. Risk of tremor and impairmentfrom tremor in relatives of patients with essential tremor: a community-based family study. Ann Neurol 2001; 49(6): 761–769.CrossRefGoogle Scholar
10. Findley, LJ. Classification of tremors. J Clin Neurophysiol 1996; 13(2): 122–132.CrossRefGoogle ScholarPubMed
11. Bain, PG, Findley, LJ, Thompson, PD, et al. A study of hereditaryessential tremor. Brain 1994; 117(Pt 4): 805–824.Google Scholar
12. Busenbark, K, Barnes, P, Lyons, K, et al. Accuracy of reported familyhistories of essential tremor. Neurology 1996; 47(1): 264–265.Google Scholar
13. Louis, ED, Ottman, R. How familial is familial tremor? The geneticepidemiology of essential tremor. Neurology 1996; 46(5): 1200–1205.Google Scholar
14. Tanner, CM, Goldman, SM, Lyons, KE, et al. Essential tremor intwins: an assessment of genetic vs environmental determinants of etiology. Neurology 2001; 57(8): 1389–1391.Google Scholar
15. Gulcher, JR, Jonsson, P, Kong, A, et al. Mapping of a familialessential tremor gene, FET1, to chromosome 3q13. Nat Genet 1997; 17(1): 84–87.Google Scholar
16. Higgins, JJ, Pho, LT, Nee, LE. A gene (ETM) for essential tremormaps to chromosome 2p22-p25. Mov Disord 1997; 12(6): 859–864.Google Scholar
17. Deuschl, G, Bergman, H. Pathophysiology of nonparkinsoniantremors. Mov Disord 2002; 17(Suppl 3): S41-S48.Google Scholar
18. Rajput, AH, Rozdilsky, B, Ang, L, Rajput, A. Clinicopathologicobservations in essential tremor: report of six cases. Neurology 1991; 41(9): 1422–1424.Google Scholar
19. Findley, L, Koller, W. Handbook of Tremor Disorders. New York, NY: Marcel Dekker; 1995.Google Scholar
20. Colebatch, JG, Findley, LJ, Frackowiak, RS, Marsden, CD, Brooks, DJ. Preliminary report: activation of the cerebellum in essential tremor. Lancet 1990; 336(8722): 1028–1030.Google Scholar
21. Wilms, H, Sievers, J, Deuschl, G. Animal models of tremor. MovDisord 1999; 14(4): 557–571.Google Scholar
22. Hallett, M. Classification and treatment of tremor. JAMA 1991; 266(8): 1115–1117.Google Scholar
23. Louis, ED, Ford, B, Lee, H, Andrews, H, Cameron, G. Diagnosticcriteria for essential tremor: a population perspective. Arch Neurol 1998; 55(6): 823–828.Google Scholar
24. Bain, P, Brin, M, Deuschl, G, et al. Criteria for the diagnosis ofessential tremor. Neurology 2000; 54(11): S7.Google Scholar
25. Brennan, KC, Jurewicz, EC, Ford, B, Pullman, SL, Louis, ED. Isessential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study. Mov Disord 2002; 17(2): 313–316.CrossRefGoogle ScholarPubMed
26. Louis, ED, Wendt, KJ, Pullman, SL, Ford, B. Is essential tremorsymmetric? Observational data from a community-based study ofessential tremor. Arch Neurol 1998; 55(12): 1553–1559.Google Scholar
27. Rajput, AH, Jamieson, H, Hirsh, S, Quraishi, A. Relative efficacy ofalcohol and propranolol in action tremor. Can J Neurol Sci 1975; 2(1): 31–35.Google Scholar
28. Lou, JS, Jankovic, J. Essential tremor: clinical correlates in 350patients. Neurology 1991; 41(2 (Pt1)): 234–238.Google Scholar
29. Growdon, JH, Shahani, BT, Young, RR. The effect of alcohol onessential tremor. Neurology 1975; 25(3): 259–262.CrossRefGoogle ScholarPubMed
30. Koller, WC. Alcoholism in essential tremor. Neurology 1983; 33(8): 1074–1076.Google Scholar
31. Koller, WC, Hristova, A, Brin, M. Pharmacologic treatment ofessential tremor. Neurology 2000; 54(11): S30-S38.Google Scholar
32. Koller, W, Graner, D, Mlcoch, A. Essential voice tremor: treatmentwith propranolol. Neurology 1985; 35(1): 106–108.Google Scholar
33. Koller, WC. Nadolol in essential tremor. Neurology 1983; 33(8): 1076–1077.Google Scholar
34. Dietrichson, P, Espen, E. Effects of timolol and atenolol on benignessential tremor: placebo-controlled studies based on quantitative tremor recording. J Neurol Neurosurg Psychiatry 1981; 44(8): 677–683.CrossRefGoogle Scholar
35. Koller, WC, Vetere-Overfield, B. Acute and chronic effects ofpropranolol and primidone in essential tremor. Neurology 1989; 39(12): 1587–1588.CrossRefGoogle Scholar
36. Sasso, E, Perucca, E, Fava, R, Calzetti, S. Primidone in the long-termtreatment of essential tremor: a prospective study with computerized quantitative analysis. Clin Neuropharmacol 1990; 13(1): 67–76.CrossRefGoogle ScholarPubMed
37. Koller, WC, Royse, VL. Efficacy of primidone in essential tremor. Neurology 1986; 36(1):121–124.CrossRefGoogle ScholarPubMed
38. O’Suilleabhain, P, Dewey, RB Jr. Randomized trial comparingprimidone initiation schedules for treating essential tremor. Mov Disord 2002; 17(2): 382–386.Google Scholar
39. Gorman, WP, Cooper, R, Pocock, P, Campbell, MJ. A comparison ofprimidone, propranolol, and placebo in essential tremor, using quantitative analysis. J Neurol Neurosurg Psychiatry 1986; 49(1): 64–68.Google Scholar
40. Thompson, C, Lang, A, Parkes, JD, Marsden, CD. A double-blind trialof clonazepam in benign essential tremor. Clin Neuropharmacol 1984; 7(1): 83–88.CrossRefGoogle Scholar
41. Huber, SJ, Paulson, GW. Efficacy of alprazolam for essential tremor. Neurology 1988; 38(2): 241–243.Google Scholar
42. Pahwa, R, Lyons, K, Hubble, JP, et al. Double-blind controlled trial ofgabapentin in essential tremor. Mov Disord 1998; 13(3): 465–467.CrossRefGoogle Scholar
43. Connor, GS. A double-blind placebo-controlled trial of topiramatetreatment for essential tremor. Neurology 2002; 59(1): 132–134.Google Scholar
44. Factor, SA, Friedman, JH. The emerging role of clozapine in thetreatment of movement disorders. Mov Disord 1997; 12(4): 483–496.CrossRefGoogle Scholar
45. Jankovic, J, Schwartz, K, Clemence, W, Aswad, A, Mordaunt, J. Arandomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor. Mov Disord 1996; 11(3): 250–256.Google Scholar
46. Brin, MF, Lyons, KE, Doucette, J, et al. A randomized, doublemasked, controlled trial of botulinum toxin type A in essentialhand tremor. Neurology 2001; 56(11): 1523–1528.Google Scholar
47. Hertegard, S, Granqvist, S, Lindestad, PA. Botulinum toxin injectionsfor essential voice tremor. Ann Otol Rhinol Laryngol 2000; 109(2): 204–209.CrossRefGoogle ScholarPubMed
48. Wissel, J, Masuhr, F, Schelosky, L, Ebersbach, G, Poewe, W. Quantitative assessment of botulinum toxin treatment in 43patients with head tremor. Mov Disord 1997; 12(5): 722–726.Google Scholar