1. Kim, L, Holena, D, Schuster, J, Sims, C, Levine, J, Pascual, JL. Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on brain imaging. J Emerg Trauma Shock. 2014;7:141-17.
2. Schaible, E-V, Thal, SC. Anticoagulation in patients with traumatic brain injury. Curr Opin Anaesthesiol. 2013;26:529-534.
3. Saiki, RL. Current and evolving management of traumatic brain injury. Crit Care Nurs Cli N Am. 2009;21:549-559.
4. Spyropoulos, AC, Hussein, M, Lin, J, Battleman, D. Rates of venous thromboembolism occurrence in medical patients among the insured population. Thromb Haemost. 2009;102:951-957.
5. Ekeh, AP, Dominguez, KM, Markert, RJ, McCarthy, MC. Incidence and risk factors for deep venous thrombosis after moderate and severe brain injury. J Trauma. 2010;68:912-915.
6. Norwood, SH, Berne, JD, Rowe, SA, Villarreal, DH, Ledlie, JT. Early venous thromboembolism prophylaxis with enoxaparin in patients with blunt traumatic brain injury. J Trauma. 2008;65:1021-1027.
7. Geerts, WH, Code, KI, Jay, RM, Chen, E, Szalai, JP. A prospective study of venous thromboembolism after major trauma. New Engl J Med. 1994;331:1601-1606.
8. Phelan, HA. Pharmacologic venous thromboembolism prophylaxis after traumatic brain injury: a critical literature review. J Neurotrauma. 2012;29:1821-1828.
9. Gross, AK, Norman, J, Cook, AM. Contemporary pharmacologic issues in the management of traumatic brain injury. J Pharm Pract. 2010;23:425-440.
10. Saadeh, Y, Gohil, K, Bill, C, et al. Chemical venous thromboembolic prophylaxis is safe and effective for patients with traumatic brain injury when started 24 hours after the absence of hemorrhage progression on head CT. J Trauma Acute Care Surg. 2012;73:426-430.
11. Reiff, DA, Haricharan, RN, Bullington, NM, Griffin, RL, McGwin, G Jr, Rue, LW III. Traumatic brain injury is associated with the development of deep vein thrombosis independent of pharmacological prophylaxis. J Trauma. 2009;66:1436-1440.
12. Foreman, PM, Schmalz, PGR, Griessenauer, CJ. Chemoprophylaxis for venous thromboembolism in traumatic brain injury: a review and evidence-based protocol. Clin Neurol Neurosurg. 2014;123:109-116.
13. Praeger, AJ, Westbrook, AJ, Nichol, AD, et al. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study. Crit Care Resusc. 2012;14:10-13.
14. Cherry, RA, Nichols, PA, Snavely, TM, David, MT, Lynch, FC. Prophylactic inferior vena cava filters: do they make a difference in trauma patients? J Trauma. 2008;65:544-548.
15. Velmahos, GC, Kern, J, Chan, LS, Oder, D, Murray, JA, Shekelle, P. Prevention of venous thromboembolism after injury: an evidence-based report--part II: analysis of risk factors and evaluation of the role of vena caval filters. J Trauma. 2000;49:140-144.
16. Lu, D, Mahmood, A, Goussev, A, et al. Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury. J Neurosurg. 2004;101:813-821.
17. Jamjoom, AAB, Jamjoom, AB. Safety and efficacy of early pharmacological thromboprophylaxis in traumatic brain injury: systematic review and meta-analysis. J Neurotrauma. 2013;30:503-511.
18. Tang, ME, Lobel, DA. Severe traumatic brain injury: maximizing outcomes. Mt Sinai J Med. 2009;76:119-128.
19. Levy, AS, Salottolo, K, Bar-Or, R, et al. D. Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injury. J Trauma. 2010;68:886-894.
20. Haddad, SH, Arabi, YM. Critical care management of severe traumatic brain injury in adults. Scand J Trauma Resusc Emerg Medicine. 2012;20:12.
21. Depew, AJ, Hu, J, Nguyen, A, Driessen, N. Thromboembolic prophylaxis is blunt traumatic intracranial hemorrhage: a retrospective review. Am Surg. 2008;74:906-911.
22. Rogers, FB, Cipolle, MD, Velmahos, G, Rzycki, G, Luchette, FA. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST Practice Management Guidelines Work Group. J Trauma. 2002;53:142-164.
23. Geerts, WH, Bergqvist, D, Pineo, GF, et al. Prevention of Venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines. 8th ed. Chest. 2008;133(6Suppl):381S-453s.
24. Carney, N, Totten, AM, O’Reilly, C, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 2017;80:6-15.
25. Moher, D, Shamseer, L, Clarke, M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. System Rev. 2015;4:1-9.
26. Phillips, B, Ball, C, Sackett, D, Badenoch, D, Straus, S. Phillips: Oxford centre for evidence-based medicine. 2009. Available at: http://www.cebm.net/oxford-centre-evidence-based-medicine-levels-evidence-march-2009. Accessed September 24, 2015.
27. Higgins, JPT, Altman, DG, Gotzsche, PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. Br Med J. 2011;343:1-9.
29. Algattas, H, Huang, J. Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury. Intl J Molec Sci. 2014;15:309-341.
30. Cowley, NJ, da Silva, EJ. Prevention of secondary brain injury following head trauma. Trauma. 2008;10:35-42.
31. Carlile, M, Nicewander, D, Yablon, SA, Brown, A, Brunner, R, Burke, D, Chae, E, Englander, J, Flanagan, S, Hamond, F, et al. Prophylaxis for venous thromboembolism during rehabilitation for traumatic brain injury: a multicenter observational study. J Trauma. 2009 Dec 1-8.
32. Elliott, B, Patel, P, Matharu, MS, Amos, R, Machin, S, Liu, C, Greenwood, R. Prophylaxis of venous thromboembolism during early inpatient rehabilitation after acquired brain injury: How guidelines change management. Disabil Rehabil. 2006;28:333-337.
33. Grenander, A, Bredbacka, S, Rydvall, A, et al. Antithrombin treatment in patients with traumatic brain injury. J Neurosurg Anesthesiol. 2001;13:49-56.
34. Vergouwen, MDI, Roos, Y, Kamphusien, PW. Venous thromboembolism prophylaxis and treatment in patients with acute stroke and traumatic brain injury. Curr Opin Crit Care. 2008;14:149-155.
35. Schoonman, GG, Bakker, DP, Jellema, K. Low risk of late intracranial complications in mild traumatic brain injury patients using oral anticoagulation after an initial normal brain computed tomography scan: education instead of hospitalization. Eur J Neurol. 2014;21:1021-1025.
36. Petruska, DA. Prophylactic anticoagulation in patients with traumatic brain injury. J Am Coll Surg. 2011;213:809.
37. Phelan, H. Venous thromboembolism after traumatic brain injury. Semin Thromb Hemostasis. 2013;39:541-548.
38. Cullen, N, Bayley, M, Bayona, N, Hilditch, M, Aubut, J. Management of heterotopic ossification and venous thromboembolism following acquired brain injury. Brain Inj. 2007;21:215-230.
39. Carlile, MC, Yablon, SA, Mysiw, WJ, Frol, AB, Lo, D, Diaz-Arrastia, R. Deep venous thrombosis management following traumatic brain injury: a practice survey of the traumatic brain injury model systems. J Head Trauma Rehabil. 2006;21:483-490.
40. Cothren, CC, Smith, WR, Moore, EE, Morgan, SJ. Utility of once-daily dose of low-molecular-weight heparin to prevent venous thromboembolism in multisystem trauma patients. World J Surg. 2006;31:98-104.
41. Kwiatt, ME, Patel, MS, Ross, SE, et al. Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2012;73:625-628.
42. Minshall, CT, Eriksson, EA, Leon, SM, Doben, AR, McKinzie, BP, Fakhry, SM. Safety and efficacy of heparin or enoxaparin prophylaxis in blunt trauma patients with a Head Abbreviated Injury Severity Score >2. J Trauma. 2011;71:396-400.
43. Lin, M, Davis, JV, Wong, DT. Evaluation of heparin prophylaxis protocol on deep venous thrombosis and pulmonary embolism in traumatic brain injury. Am Surg. 2013;79:1050-1053.
44. Agnelli, G, Piovella, F, Buoncristiani, P, et al. Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. New Engl J Med. 1998;339:80-85.
45. Nathens, AB, McMurray, MK, Cuschieri, J, et al. The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma. 2007;62:557-563.
46. Farooqui, A, Hiser, B, Barnes, SL, Litofsky, NS. Safety and efficacy of early thromboembolism chemoprophylaxis after intracranial hemorrhage from traumatic brain injury. J Neurosurg. 2013;119:1576-1582.
47. Scudday, T, Brasel, K, Webb, T, et al. Safety and efficacy of prophylactic anticoagulation in patients with traumatic brain injury. J Am Coll Surg. 2011;213:148-153.
48. Kleindienst, A, Harvey, HB, Mater, E, et al. Early antithrombotic prophylaxis with low molecular weight heparin in neurosurgery. Acta Neurochir. 2003;145:1085-1091.
49. Koehler, DM, Shipman, J, Davidson, MA, Guillamondegui, O. Is Early venous thromboembolism prophylaxis safe in trauma patients with intracranial hemorrhage. J Trauma. 2011;70:324-329.
50. Nickele, CM, Kamps, TK, Medow, JE. Safety of a DVT chemoprophylaxis protocol following traumatic brain injury: a single center quality improvement initiative. Neurocrit Care. 2012;18:184-192.
51. Phelan, HA, Wolf, SE, Norwood, SH, et al. A randomized, double-blinded, placebo-controlled pilot trial of anticoagulation in low-risk traumatic brain injury. J Trauma Acute Care Surg. 2012;73:1434-1441.
52. Salottolo, K, Offner, P, Levy, AS, Mains, CW, Slone, DS, Bar-Or, D. Interrupted pharmocologic thromboprophylaxis increases venous thromboembolism in traumatic brain injury. J Trauma. 2011;70:19-26.
53. Callcut, RA, Hanseman, DJ, Solan, PD, et al. Early treatment of blunt cerebrovascular injury with concomitant hemorrhagic neurologic injury is safe and effective. J Trauma. 2011;72:338-346.
54. Dudley, RR, Aziz, I, Bonnici, A, et al. Early venous thromboembolic event prophylaxis in traumatic brain injury with low-molecular-weight heparin: risks and benefits. J Neurotrauma. 2010;27:2165-2172.
55. Norwood, SH, McAuley, CE, Berne, JD, et al. Prospective evaluation of the safety of enoxaparin prophylaxis for venous thromboembolism in patients with intracranial hemorrhagic injuries. Arch Surg. 2002;137:696-702.
56. Kurtoglu, M, Yanar, H, Bilsel, Y, et al. Venous thromboembolism prophylaxis after head and spinal trauma: Intermittent pneumatic compression devices versus low molecular weight heparin. World J Surg. 2004;28:807-811.
57. Kim, J, Gearhart, MM, Zurick, A, Zuccarello, M, James, L, Luchette, FA. Preliminary report on the safety of heparin for deep venous thrombosis prophylaxis after severe head injury. J Trauma. 2002;53:38-43.
58. Byrne, JP, Geerts, W, Mason, SA, et al. Effectiveness of low-molecular-weight-heparin versus unfractionated heparin to prevent pulmonary embolism following major trauma: a propensity-matched analysis. The J Trauma Acute Care Surg. 2017;82:252-262.
59. Greinacher, A, Alban, S, Omer-Adam, MA, Weitschies, W, Warkentin, TE. Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight-heparin, and fondaparinux in different clinical settings. Thromb Res. 2008;122:211-220.
60. Allison, RZ, Nakagawa, K, Hayashi, M, Donavan, DJ, Koenig, MA. Derivation of a predictive score for hemorrhagic progression of cerebral contusions in moderate and severe traumatic brain injury. Neurocrit Care. 2017;26:80-86.
61. Zhang, D, Gong, S, Jin, H, et al. Coagulation parameters and risk of progressive hemorrhagic injury after traumatic brain injury: systematic review and meta-analysis. BioMed Res Int. 2015;2015:261825.
62. Kelly, J, Rudd, A, Lewis, RR, Hunt, BJ. Screening for subclinical deep-vein thrombosis. QJM.. 2001;94:511-519.