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Studies on the role of taurine in Friedreich's ataxia

Published online by Cambridge University Press:  18 September 2015

B. Lemieux ,
R. Giguère  and
D. Shapcott
B. Lemieux
Affiliation:
Le Centre Hospitalier Universitaire de L'Universitd de Sherbrooke
R. Giguère
Affiliation:
Le Centre Hospitalier Universitaire de L'Universitd de Sherbrooke
D. Shapcott
Affiliation:
Le Centre Hospitalier Universitaire de L'Universitd de Sherbrooke
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Abstract

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New studies were undertaken to verify the previous findings of increased urinary excretion of taurine, in the basal state and after challenge with a taurine load, in Friedreich's disease. Particular attention was paid to possible causes of error such as weight, muscle mass, creatine and creatinine excretion, variability with time and appropriate control groups. Although the overall findings were confirmed, their interpretation is open to question because of all these factors of error. Many possibilities must still be further explored to account for the apparent taurine retention defect observed in many cases of Friedreich's disease.

Type
C—Biochemistry
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 610 - 615
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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