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Studies of Human Papovavirus Tumor Antigen in Experimental and Human Cerebral Neoplasms

Published online by Cambridge University Press:  18 September 2015

L.E. Becker ,
O. Narayan  and
R.T. Johnson
L.E. Becker*
Affiliation:
Departments of Animal Medicine and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland and the Department of Pathology, University of Toronto, Toronto, Ontario
O. Narayan
Affiliation:
Departments of Animal Medicine and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland and the Department of Pathology, University of Toronto, Toronto, Ontario
R.T. Johnson
Affiliation:
Departments of Animal Medicine and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland and the Department of Pathology, University of Toronto, Toronto, Ontario
*
Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8
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Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 2 , May 1976 , pp. 105 - 109
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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