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Sleep, Subcortical Stimulation and Kindling in the Cat

Published online by Cambridge University Press:  18 September 2015

T. Tanaka ,
H. Lange  and
R. Naquet
T. Tanaka*
Affiliation:
Centre National de la Recherche Scientifique, Gif-Sur-Yvette, France
H. Lange
Affiliation:
Centre National de la Recherche Scientifique, Gif-Sur-Yvette, France
R. Naquet*
Affiliation:
Centre National de la Recherche Scientifique, Gif-Sur-Yvette, France
*
Laboratoire de Physiologie Nerveuse, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France
Laboratoire de Physiologie Nerveuse, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France
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A longitudinal study of the effects of sleep on amygdaloid kindling showed that kindling disrupted normal sleep patterns by reducing REM sleep and increasing awake time. Few interictal spike discharges were observed during the awake stage, while a marked increase in discharge was observed during the light and deep sleep stages. No discharges were observed during REM sleep. During the immediate post-stimulation period the nonstimulated amygdala showed a much higher rate of spike discharge. On the other hand, there was an increase in spike discharge in the stimulated amygdala during natural sleep without preceding amygdaloid stimulation. Amygdaloid stimulation at the generalized seizure threshold during each sleep stage resulted in a generalized convulsion.

The influence of subcortical electrical stimulation on kindled amygdaloid convulsions was investigated in a second experiment. Stimulation of the centre median and the caudate nucleus was without effect on kindled convulsions, while stimulation of the mesencephalic reticular formation at high frequency (300 Hz) reduced the latency of onset of kindled generalized convulsions. Stimulation of the nucleus ventralis lateralis of the thalamus at low frequency (10 Hz) prolonged the convulsion latency, and at high current levels blocked the induced convulsion. Stimulation in the central gray matter at low frequency (10 Hz) also blocked kindled amygdaloid convulsions.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 447 - 455
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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