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Serum Lipoprotein Fatty Acid Profile in Hereditary Ataxias

Published online by Cambridge University Press:  18 September 2015

L. Iorio ,
G. De Michele ,
A. Filla ,
L. Di Martino ,
A. Postiglione ,
L. Patti  and
G. Campanella
L. Iorio*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
G. De Michele*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
A. Filla*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
L. Di Martino*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
A. Postiglione*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
L. Patti*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
G. Campanella*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
*
Clinica Neurologica. Seconda Facoltà di Medicina, via Pansini 5, 80131 Napoli, Italy
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Abstract:

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We investigated the serum fatty acid profiles of cholesterol esters, phospholipids and triglycerides in 24 patients with Friedreich's disease and 16 patients with other forms of spinocerebellar degeneration. In 8 patients with Friedreich's disease we also analyzed the fatty acid profile of the lipoprotein fractions. We found no major differences in fatty acid profiles between ataxic patients and sex and age-matched controls; in particular there was no decrease of linoleic acid in Friedreich's disease. The level of linoleic acid in serum cholesterol esters decreased with increasing disability of patients.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 3 , August 1993 , pp. 206 - 209
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

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