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Relationships Between Psychological Measurements and Cerebral Organic Changes in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

H. Merskey ,
M.J. Ball ,
W.T. Blume ,
Allan J. Fox ,
Hannah Fox ,
E.L. Hersch ,
V.A. Kral  and
R.B. Palmer
H. Merskey*
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
M.J. Ball
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
W.T. Blume
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
Allan J. Fox
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
Hannah Fox
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
E.L. Hersch
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
V.A. Kral
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
R.B. Palmer
Affiliation:
Depts. of Psychiatry, Clinical Neurological Sciences, and Pathology, The University of Western Ontario, and The London Psychiatric Hospital, LondonOntario
*
London Psychiatric Hospital, 850 Highbury Ave., P.O. Box 2532 Terminal “A” London, Ont. Canada N6A 4H1
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Twenty-two patients were carefully defined as having progressive dementia without other known cause and not complicated by clinical or laboratory evidence of multiinfarct dementia. Their degree of dementia measured by the ESD correlated highly with EEG disturbance (r=-0.79). The LPRS correlated 0.73 with ventricular enlargement. Although the EEG and CT scan only correlated significantly with each other in advanced cases, a combined index of EEG and CT Scan change, (Physical Meaasures Index) achieved a correlation of 0.93 with a combined index of psychological change (Psychological Measures Index). The results indicate the possibility of using physical and psychological measures to monitor quantitative change in Alzheimer's Disease, the EEG contributing more initially and the CT scan more in the most advanced cases.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 1 , February 1980 , pp. 45 - 49
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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