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A Prospective Study of 50 Cases of Familial Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

Madeleine Roy ,
Liette Boyer  and
André Barbeau
Madeleine Roy
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
Liette Boyer
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
André Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
110 West Pine Avenue, Montreal, Quebec, Canada H2W 1R7.
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In a recent paper (Barbeau and Pourcher, 1982) we demonstrated that so-called “idiopathic” Parkinson’s disease is not a homogeneous entity, and defined the existence of a sub-group of patients with genetic parkinsonism. To investigate this last possibility, and to uncover possible metabolic clues as to the etiology of such cases, we carried out a prospective study of 50 kindreds with “familial” parkinsonism. Two control groups were similarly studied: 50 kindreds with essential tremor (neurological control group) and 50 kindreds originating from spouses of the previous patients (non neurological control group). We uncovered two main patterns of genetic transmission within the parkinsonian patients: a parkinsonism related to dominant essential tremor (34 kindreds; 10% of all Parkinsonians) and a recessive “akineto-rigid syndrome” (10 kindreds; 3–4% of all Parkinsonians). A further 4 kindreds assumed a pseudo-dominant pattern but were probably recessive. Finally 2 kindreds were obviously other entities presenting as “phenocopies” of Parkinson’s disease. Metabolically, hyperthyroidism appeared to be more frequent in essential tremor and “essential-tremor related parkinsonism” kindreds, while hypothyroidism and possibly hypoparathyroidism (post surgery) seemed more frequent in the recessive akineto-rigid syndrome kindreds.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 37 - 42
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

References

Allan, W. (1937). Inheritance of the Shaking Palsy. Arch. Int. Med. 60:424–436.CrossRefGoogle Scholar
Barbeau, A. and Pourcher, E. (1982). New Data on the Genetics of Parkinson’s Disease. Can. J. Neurol. Sci. 9: 53–60.CrossRefGoogle ScholarPubMed
Barbeau, A. and Raymond-Tremblay, D.. (1965). Recent biochemical studies in Parkinson’s disease and position of the problem. In: Parkinson’s Disease – Trends in Research and Treatment. (Ed. Barbeau, A.; Doshay, L. and Spiegel, E.A.). Grune and Stratton, pp. 79–94.Google Scholar
Berger, J.R. and Ross, D.B. (1981). Reversible Parkinson Syndrome complicating post-operative hypoparathyroidism. Neurology (NY) 31: 881–882.CrossRefGoogle Scholar
Kondo, K., Kurland, L.T. and Schull, W.J. (1973). Parkinson’s disease. Genetic Analysis and Evidence of a Multifactorial Etiology. Mayo Clinic Proc. 48: 465–475.Google ScholarPubMed
Martilla, R.J. and Rinne, U.K. (1976). Epidemiology of Parkinson’s disease in Finland. Acta Neurol. Scandinav. 53:81–102.Google Scholar
Martin, W.E., Yound, W.I. and Anderson, V.E. (1973). Parkinson’s Disease – A genetic study. Brain 96: 495–506.CrossRefGoogle ScholarPubMed
Mjönes, H. (1949). Paralysis Agitans: A clinical and genetic study. Acta Psychiat. Scand. (Suppl. 54) p. 1–130.Google Scholar
Perry, T.L., Bratty, P.J.A., Hansen, S., Kennedy, J., Urquhart, N. and Dolman, C.L. (1975). Hereditary mental depression and Parkinsonism with taurine deficiency. Arch. Neurol. 32: 108–113.CrossRefGoogle ScholarPubMed
Romanul, F.C.A., Fowler, H.L. and Radvany, J. (1977). Azorean disease of the nervous system. New England J. Med. 296: 1505–1508.CrossRefGoogle ScholarPubMed
Tune, L.E., Folstein, M., Rabins, P., Jayaram, G. and McHugh, P. (1982). Familial manic-depressive illness and familial Parkinson’s disease: – a case report. Johns Hopkins Med. 151:65–70.Google ScholarPubMed
Yokochi, M. and Narabayashi, H. (1981). Clinical characteristics of juvenile Parkinsonism. In: Research Progress in Parkinson’s disease. (Rose, F.C. and Capildeo, R., Editors). Pitman Medical, Kent, Great Britian. pp. 35–39.Google Scholar