Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-06-24T01:38:54.375Z Has data issue: false hasContentIssue false
  • English
  • Français

Primary Hypothyroidism Presenting as Growth Delay and Pituitary Enlargement

Published online by Cambridge University Press:  18 September 2015

John D. Farley ,
Ellen L. Toth  and
Edmond A. Ryan
John D. Farley
Affiliation:
Division of Endocrinology and Metabolism, University of Alberta, Edmonton
Ellen L. Toth
Affiliation:
Division of Endocrinology and Metabolism, University of Alberta, Edmonton
Edmond A. Ryan*
Affiliation:
Division of Endocrinology and Metabolism, University of Alberta, Edmonton
*
7-118 Clinical Science Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We report the case of a young boy being considered for pituitary surgery because of pituitary enlargement found during assessment of growth delay. There was no goitre but he was hypothyroid clinically and biochemically. The finding of an elevated TSH suggested primary thyroid disease with thyrotroph hyperplasia. Treatment with L-thyroxine resulted in prompt resolution of his pituitary enlargement and improvement in his visual fields.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 1 , February 1988 , pp. 35 - 37
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

REFERENCES

1.Niepce, B. Traite du Goitre et du Cretinisme. Baillieri, JB, ed. Paris, 1851.Google Scholar
2.Tur-kaspa, R, Home, T, Landau, H, et al. Pituitary enlargement secondary to hypothyroidism associated with sublingual thyroid gland. Isr J Med Sci 1979; 15: 772–774.Google ScholarPubMed
3.Samaan, NA, Osborne, BM, Mackay, B, et al. Endocrine and morphologic studies of pituitary adenomas secondary to primary hypothyroidism. J Clin Endocrinol Metab 1977; 45: 903–911.CrossRefGoogle ScholarPubMed
4.Khalil, A, Kovacs, K, Sima, AAF, et al. Pituitary thyrotroph hyperplasia mimicking prolactin – secreting adenoma. J Endocrinol Invest 1984; 7: 399–404.CrossRefGoogle ScholarPubMed
5.Yamamoto, K, Saito, K, Takaji, T, et al. Visual field defects and pituitary enlargement in primary hypothyroidism. J Clin Endocrinol Metab 1983; 57: 283–287.CrossRefGoogle ScholarPubMed
6.Scheithauer, BW, Kovac, K, Randall, RV, et al. Pituitary gland in hypothyroidism. Arch Pathol Lab Med 1985; 109:499–504.Google ScholarPubMed
7.Nishi, Y, Sakano, T, Hyodo, S, et al. Pituitary abnormalities detected by high resolution computed tomography with thin slices in primary hypothyroidism and Turner syndrome. Eur J Pediatr 1984; 142: 25–28.CrossRefGoogle ScholarPubMed
8.Vagenakis, AG, Dole, K, Braverman, LE. Pituitary enlargement, pituitary failure and primary hypothyroidism. Ann Intern Med 1976; 85: 195–198.CrossRefGoogle ScholarPubMed
9.Lecky, BRF, Williams, TDM, Lightman, SL, et al. Myxaedema presenting with chiasmal compression: Resolution after thyroxine replacement. Lancet 1987; 1: 1347–1350.CrossRefGoogle Scholar
10.Suter, SN, Kaplan, SL, Ankert, ML, et al. Plasma prolactin and thyrotropin and the response to thyrotropin-releasing factor in children with primary and hypothalamic hypothyroidism. J Clin Endocrinol Metab 1978; 47: 1015–1020.CrossRefGoogle ScholarPubMed
11.Stockigt, JR, Essex, WB, West, RH, et al. Visual failure during replacement therapy in primary hypothyroidism with pituitary enlargement. J Clin Endocrinol Metab 1976; 43: 1094–1100.CrossRefGoogle ScholarPubMed
12.Van Dop, C, Conte, FA, Koch, TK, et al. Pseudo-tumor cerebri associated with initiation of Levo Thyroxine therapy for juvenile hypothyroidism.? Engl J Med 1983; 308: 1076–1080.CrossRefGoogle Scholar
13.Samaan, NA, Stepanas, AV, Danziger, J, et al. Reactive pituitary abnormalities in patients with Klinefelter’s and Turner’s syndromes. Arch Intern Med 1979; 139: 198–201.CrossRefGoogle ScholarPubMed
14.Daughaday, WH. The Anterior Pituitary. In: Wilson, JD and Foster, DW, eds. Williams Textbook of Endocrinology. Philadelphia, WB Saunders, 1985, p. 591.Google Scholar