Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-23T23:58:14.444Z Has data issue: false hasContentIssue false

Prevalence of Glaucoma in Hospitalized Older Adults with Alzheimer's Disease

Published online by Cambridge University Press:  23 September 2014

Andrée-Anne Pelletier
Affiliation:
School of Optometry, l'Université de Montréal, Montréal, Québec, Canada
Marie-Ève Théorêt
Affiliation:
School of Optometry, l'Université de Montréal, Montréal, Québec, Canada
Tanguy Boutin
Affiliation:
Faculty of Medicine, l’Université de Montréal, Montréal, Québec, Canada
Marie-Jeanne Kergoat*
Affiliation:
Faculty of Medicine, l’Université de Montréal, Montréal, Québec, Canada Institut universitaire de gériatrie de Montréal, l’Université de Montréal, Montréal, Québec, Canada
Fadi Massoud
Affiliation:
Faculty of Medicine, l’Université de Montréal, Montréal, Québec, Canada Institut universitaire de gériatrie de Montréal, l’Université de Montréal, Montréal, Québec, Canada Centre hospitalier de l’Université de Montréal, l’Université de Montréal, Montréal, Québec, Canada
Judith Latour
Affiliation:
Faculty of Medicine, l’Université de Montréal, Montréal, Québec, Canada Institut universitaire de gériatrie de Montréal, l’Université de Montréal, Montréal, Québec, Canada Centre hospitalier de l’Université de Montréal, l’Université de Montréal, Montréal, Québec, Canada
Céline Chayer
Affiliation:
Faculty of Medicine, l’Université de Montréal, Montréal, Québec, Canada Institut universitaire de gériatrie de Montréal, l’Université de Montréal, Montréal, Québec, Canada Centre hospitalier de l’Université de Montréal, l’Université de Montréal, Montréal, Québec, Canada Hôpital Maisonneuve-Rosemont, l’Université de Montréal, Montréal, Québec, Canada
Hélène Kergoat
Affiliation:
School of Optometry, l'Université de Montréal, Montréal, Québec, Canada Institut universitaire de gériatrie de Montréal, l’Université de Montréal, Montréal, Québec, Canada
*
School of Optometry, University of Montreal, Succ. Centre-ville; Montréal, Québec, H3C 3J7, Canada. Email: helene.kergoat@umontreal.ca
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

To determine the prevalence of glaucoma in older adults with dementia of the alzheimer's type (DAT).

Methods:

retrospective chart review: the prevalence of glaucoma was determined in older adults with a diagnosis of DAT or mixed dementia (DAT with vascular contribution) admitted to the geriatric and neurology units of the Centre hospitalier de l'université de Montréal and the hôpital Maisonneuve-rosemont between april 2008 and april 2009 (n=220; DAT group). they were matched for age and date of hospitalisation to the first 220 individuals without dementia (control group) recruited from other medical units in the same hospitals: gastroenterology, internal medicine or cardiology. a diagnosis of glaucoma was deemed positive if recorded in the chart or if there was a medication compatible with this diagnosis. Chi-square tests were used for between-group comparisons.

Results:

Subjects' age ranged from 66 to 101 years. the prevalence of glaucoma was 6.8% in our study population (n=30/440). glaucoma was significantly more prevalent in the DAT group (n= 21; 9.5%) than in the control group (n= 9; 4.1%) [χ1 2 = 5.15; p = 0.023].

Conclusions:

the prevalence of glaucoma was higher in a group of older adults with DAT than in a comparable control group. these results underscore the importance of providing regular eyecare for persons affected by DAT.

Type
Original Article
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Population and demography. Statistics Canada, 2010. Canada Year Book 2010. Catalogue no. 11-402-X. p. 315. Available from: http://www.statcan.gc.ca/pub/11-402-x/2010000/pdf/population-eng.pdf.Google Scholar
2.Population projections 1990–2011 based on recent changes in fertility levels and revised immigration targets (cat no 91–520), Statistics Canada, Ottawa, 1989.Google Scholar
3.Canadian study of health and aging. The Canadian study of health and aging: study methods and prevalence of dementia in Canada. Can Med Assoc J. 1994;150:899914.Google Scholar
4.Millar, WJ.Problèmes de vision chez les personnes âgées, Rapports sur la santé, vol. 16, no 1, octobre 2004 Statistique Canada, no 82-003 au catalogue p. 49–54.Google Scholar
5.World Health Organization. Prevention of blindness and visual impairment. Accessed on July 16, 2013. Available from: http://www.who.int/blindness/causes/en/Google Scholar
6.Resnikoff, S, Pascolini, D, Etaya’ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82:84451.Google Scholar
7.Shiose, Y, Kitazawa, Y, Tsukahara, S, et al. Epidemiology of glaucoma in Japan: a nationwide glaucoma survey. Jpn J Ophthalmol. 1991;35:13355.Google ScholarPubMed
8.Henderson, VW.The epidemiology of estrogen replacement therapy and Alzheimer’s disease. Neurology. 1997;48:2735.CrossRefGoogle ScholarPubMed
9.Quigley, HA.Glaucoma. Lancet. 2011;377:136777.Google Scholar
10.Hinton, DR, Sadun, AA, Blanks, JC, Miller, CA.Optic-nerve degeneration in Alzheimer’s disease. N Engl J Med. 1986;315:4857.CrossRefGoogle ScholarPubMed
11.Blanks, JC, Hinton, DR, Sadun, AA, Miller, CA.Retinal ganglion cell degeneration in Alzheimer’s disease. Brain Res. 1989;501:36472.Google Scholar
12.Trick, GL, Barris, MC, Bickler-Bluth, M.Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer type. Ann Neurol. 1989;26:22631.Google Scholar
13.Trick, GL, Trick, LR, Morris, P, Wolf, M.Visual field loss in senile dementia of the Alzheimer’s type. Neurology. 1995;45:6874.Google Scholar
14.Curcio, CA, Drucker, DN.Retinal ganglion cells in Alzheimer’s disease and aging. Ann Neurol. 1993;33:24857.Google Scholar
15.Davies, DC, McCoubrie, P, McDonald, B, Jobst, KA.Myelinated axon number in the optic nerve is unaffected by Alzheimer’s disease. Br J Ophthalmol. 1995;79:596600.CrossRefGoogle ScholarPubMed
16.Kergoat, H, Kergoat, MJ, Justino, L, Chertkow, H, Robillard, A, Bergman, H.Visual retinocortical function in dementia of the Alzheimer type. Gerontology. 2002;48:197203.CrossRefGoogle ScholarPubMed
17.Saunders, AM, Strittmatter, WJ, Schmechel, D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology. 1993;43:146772.Google Scholar
18.Vickers, JC, Craig, JE, Stankovich, J, et al. The apolipoprotein e4 gene is associated with elevated risk of normal tension glaucoma. Mol Vis. 2002;8:38993.Google Scholar
19.Al-Dabbagh, NM, Al-Dohayan, N, Arfin, M, Tariq, M.Apolipoprotein E polymorphisms and primary glaucoma in Saudis. Mol Vis. 2009;15:9129.Google ScholarPubMed
20.Lake, S, Liverani, E, Desai, M, et al. Normal tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms. Br J Ophthalmol. 2004;88:4913.Google Scholar
21.Ressiniotis, T, Griffiths, PG, Birch, M, Keers, S, Chinnery, PF.The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma. Arch Ophthalmol. 2004;122:25861.Google Scholar
22.Zetterberg, M, Tasa, G, Palmér MS, et al. Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. J Ophthalmol. 2007;143:105960.Google Scholar
23.Tamura, H, Kawakami, H, Kanamoto, T, et al. High frequency of open-angle glaucoma in Japanese patients with Alzheimer’s disease. J Neurol Sci. 2006;246:7983.Google Scholar
24.Guo, L, Salt, TE, Luong, V, et al. Targeting amyloid-β in glaucoma treatment. Proc Natl Acad Sci USA. 2007;104:134449.Google Scholar
25.Kipfer-Kauer, A, McKinnon, SJ, Frueh, BE, Goldblum, D.Distribution of amyloid precursor protein and amyloid-β in ocular hypertensive C57BL/6 mouse eyes. Curr Eye Res. 2010;35:82834.CrossRefGoogle ScholarPubMed
26.Gupta, N, Fong, J, Ang, LC, Yucel, YH.Retinal tau pathology in human glaucomas. Can J Ophthalmol. 2008;41:5360.Google Scholar
27.Wostyn, P, Audenaert, K, De Deyn, PP.Alzheimer’s disease and glaucoma: Is there a causal relationship? Br J Ophthalmol. 2009;93:15579.CrossRefGoogle ScholarPubMed
28.Berdahl, JP, Allingham, RR, Johnson, DH.Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology. 2008;115:7638.CrossRefGoogle ScholarPubMed
29.Chandra, V, Bharucha, NE, Schoenberg, BS.Conditions associated with Alzheimer’s disease at death. Case-control study. Neurology. 1986;36:20911.Google Scholar
30.Bayer, AU, Ferrari, F, Erb, C.High occurrence rate of glaucoma among patients with Alzheimer’s disease. Eur Neurol. 2002;47:1658.Google Scholar
31.Bayer, AU, Keller, ON, Ferrari, F, Maag, KP.Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer’s disease and Parkinson’s disease. Am J Ophthalmol. 2002;133:1357.Google Scholar
32.Bayer, AU, Ferrari, F.Severe progression of glaucomatous optic neuropathy in patients with Alzheimer’s disease. Eye. 2002;16:20912.Google Scholar
33.Kessing, LV, Lopez, AG, Andersen, PK, Kessing, SV.No increased risk of developing Alzheimer disease in patients with glaucoma. J Glaucoma. 2007;16:4751.Google Scholar
34.Bach-Holm, D, Kessing, SV, Mogensen, U, Forman, JL, Andersen, PK, Kessing, LV.Normal tension glaucoma and Alzheimer disease: comorbidity? Acta Ophthalmol. 2012;90:6835.CrossRefGoogle ScholarPubMed
35.Ou, Y, Grossman, DS, Lee, PP, Sloan, FA.Glaucoma, , Alzheimer disease and other dementia: A longitudinal analysis. Ophthalmic Epidemiol. 2012;19:28592.Google Scholar
36.American Psychiatric Association. DSM-IV-TR 2000. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC.Google Scholar
37.McKhann, GM, Knopman, DS, Chertkow, H, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:2639.Google Scholar
38.The national coalition for vision health. Foundations for a Canadian vision health strategy. 2007;16.Google Scholar
39.Van der Pols, JC, Bates, CJ, McGraw, PV, et al. Visual acuity measurements in a national sample of British elderly people. Br J Ophthalmol. 2000;84:16570.Google Scholar
40.Kergoat, H, Boisjoly, H, Freeman, EE, et al. The perceived needs and availability of eye care services for older adults in Quebec nursing homes. Am Acad Optom. 2012; Abstract # 120036.Google Scholar
41.Lawrence, V, Murray, J, ffytche, D, et al. “Out of sight, out of mind”: a qualitative study of visual impairment and dementia from three perspectives. Intern Psychogeriatrics. 2009;21:5118.Google Scholar
42.Inouye, SK, Viscoli, CM, Horwitz, RI, et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med. 1993;119:47481.Google Scholar