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Pituitary Melanocorticotrophinoma with Amyloid Deposition

Published online by Cambridge University Press:  18 September 2015

Juan M. Bilbao ,
Kalman Kovacs ,
Eva Horvath ,
Hubert P. Higgins  and
William J. Horsey
Juan M. Bilbao*
Affiliation:
Departments of Pathology, Endocrinology and Neurosurgery, St. Michael’s Hospital and University of Toronto
Kalman Kovacs
Affiliation:
Departments of Pathology, Endocrinology and Neurosurgery, St. Michael’s Hospital and University of Toronto
Eva Horvath
Affiliation:
Departments of Pathology, Endocrinology and Neurosurgery, St. Michael’s Hospital and University of Toronto
Hubert P. Higgins
Affiliation:
Departments of Pathology, Endocrinology and Neurosurgery, St. Michael’s Hospital and University of Toronto
William J. Horsey
Affiliation:
Departments of Pathology, Endocrinology and Neurosurgery, St. Michael’s Hospital and University of Toronto
*
Department of Pathology, St. Michael’s Hospital, Toronto, Ontario M5B 1W8
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Summary:

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The light and electron microscopic features of a pituitary adenoma composed of adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH) cells with perivascular amyloid deposition is reported. Histochemical and fine structural data indicate that this material is APUDamyloid and is present in the extra-cellular perivascular spaces. It is suggested that the differences in fine structure and of distribution of the amyloid in pituitary adenomas is dependent upon the cell of origin.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 3 , August 1975 , pp. 199 - 202
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

REFERENCES

Bilbao, J.M., Horvath, E., Hudson, A.R., and Kovacs, K. (1975). Pituitary adenoma producing amyloid-like substance. A histologic, histochemical and ultrastructural study of a case. Archives of Pathology, in press.Google Scholar
Ibanez, M.L. (1974). Medullary carcinoma of the thyroid gland. In Pathology Annual edited by Sommers, S.C.Appleton-Century-Crofts, New York.Google ScholarPubMed
Pearse, A.G.E. (1968). Histochemistry, theoretical and applied. Third edition. Vol. 1. J. and A. Churchill Ltd., London, pages 133–136, chapter 6.Google Scholar
Pearse, A.G.E., Ewen, S.W.B., and Polak, J.M. (1972). The genesis of apudamyloid in endocrine polypeptide tumours: Histochemical distinction from immunoamyloid. Virchows Archiv; abteilung B: Zellpathologie, 10, 93–107.Google Scholar
Pearse, A.G.E. (1974). The APUD cell concept and its implications in Pathology. In Pathology Annual edited by Sommers, S.C.Appleton-Century-Crofts, New York.Google Scholar
Rovit, R.L.Berry, R. (1965). Cushing’s syndrome and the hypophysis. Journal of Neurosurgery, 23, 270–295.CrossRefGoogle ScholarPubMed
Saeger, W. (1973). Zur Ultrastruktur der Hypophysenadenoma beim Cushing-Syndrom nach Adrenalektomie. Virchows Archiv; Abteilung A: Pathologische Anatomie, 361, 39–50.CrossRefGoogle Scholar
Shirahama, T., and Cohen, A.S. (1967). High resolution electron microscopic analysis of the amyloid fibril. Journal of Cell Biology, 33, 679–708.CrossRefGoogle ScholarPubMed
Takor Takor, T., Pearse, A.G.E. (1973). Cytochemical identification of human and murine pituitary corticotrophs as APUD cells. Histochemie, 37, 207–214.CrossRefGoogle ScholarPubMed