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The Pharmacology of Chewable Versus Regular Carbamazepine in Chronically Treated Children With Epilepsy

Published online by Cambridge University Press:  18 September 2015

Peter Camfield
Affiliation:
IWK Children’s Hospital, Department of Pediatrics, Dalhousie University, Halifax
Paul Hwang
Affiliation:
Division of Neurology, the Hospital for Sick Children, University of Toronto, Toronto
Carol Camfield*
Affiliation:
IWK Children’s Hospital, Department of Pediatrics, Dalhousie University, Halifax
Albert Fraser
Affiliation:
Department of Toxicology, Victoria General Hospital, Halifax
Steven Soldin
Affiliation:
Children’s Hospital National Medical Center, Department of Laboratory Medicine, Washington, D.C.
AK Al-Quadah
Affiliation:
Division of Neurology, the Hospital for Sick Children, University of Toronto, Toronto
*
IWK Children’s Hospital, Box 3070, Halifax, Nova Scotia, Canada B3J 3G9
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Abstract:

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We report the first comparison of Chewable and Regular Carbamazepine (CBZ) tablets in children with epilepsy. Forty-four children receiving chronic monotherapy CBZ participated. In month 1 children received regular CBZ; in month 2, the same dose of Chewable CBZ. Once per week fasting predose CBZ and CBZ epoxide serum levels were determined. In a subset of 15 children, at the end of each month serum levels were obtained every 2 hours for 12 hours beginning pre-dose. Standards for CBZ and CBZ epoxide were tested in each centre. Overall, weekly levels showed no consistent differences between the month on chewable CBZ and regular CBZ. Seizure control and rates of reported side effects were similar. In five patients chewable CBZ produced higher peak CBZ levels while five had higher peaks with regular CBZ. In conclusion, regular and chewable CBZ often have unpredictable differences in peak but not trough levels of CBZ suggesting that peak level side effects with one form of CBZ might be alleviated by changing to the other.

Type
Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

References

1.Dodson, WE.Carbamazepine efficacy and utilization in children. Epilepsia 1987; 28 (Suppl 3): s17s24.CrossRefGoogle ScholarPubMed
2.Soldin, SJ.High performance liquid chromatographic analysis of anti-convulsant drugs using radial compression columns. Clin Biochem 1980; 13:99101.CrossRefGoogle ScholarPubMed
3.Fraser, AD, Camfield, PR, Weaver, D.Clinical pharmacokinetic features of severe carbamazepine poisoning. Clin Biochem 1987; 20: 296.CrossRefGoogle Scholar
4.Bauer, LA.Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology 1982; 32: 570572.Google ScholarPubMed
5.Maas, B, Garnett, WR, Pellock, JM, Comstock, TJ.A comparative bioavailability study of carbamazepine tablets and a chewable tablet formulation. Ther Drug Monit 1987; 9: 2833.CrossRefGoogle Scholar
6.Aldenkamp, AP, Alpherts, MC, Moerland, MC, Ottevanger, N, Van Parys, JAP.Controlled release carbamazepine: cognitive side effects in patients with epilepsy. Epilepsia 1987; 28: 507514.CrossRefGoogle ScholarPubMed