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PET Studies of Parkinsonian Patients Treated with Autologous Adrenal Implants

Published online by Cambridge University Press:  18 September 2015

M. Guttman ,
R.S. Burns ,
W.R.W. Martin ,
R.F. Peppard ,
M.J. Adam ,
T.J. Ruth ,
G. Allen ,
R.A. Parker ,
N.B. Tulipan  and
D.B. Calne
M. Guttman*
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
R.S. Burns
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
W.R.W. Martin
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
R.F. Peppard
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
M.J. Adam
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
T.J. Ruth
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
G. Allen
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
R.A. Parker
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
N.B. Tulipan
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
D.B. Calne
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
*
3801 University, Montreal, Quebec, Canada H3A 2B4
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Abstract:

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Transplantation of autologous adrenal medulla tissue into the striatum has recently been proposed as a treatment for Parkinson's disease. We report the use of positron emission tomography (PET) to evaluate patients who had adrenal implants placed into the right caudate. 6-[18F] fluoro-L-dopa (6-FD) scans were performed to study the integrity and activity of the implant, and the nigrostriatal dopamine system before and six weeks after transplantation surgery. [68Ga] Gallium-ethylenediaminetetraacetate (Ga) scans were also performed to assess the blood brain barrier. The Ga scans performed on two patients showed increased permeability of the blood brain barrier at the surgical site. 6-FD PET scans in five patients did not show a consistent change in striatal uptake following adrenal medullary implantation after six weeks. Further assessment of implant viability with 6-FD PET scans after longer follow up may provide useful information if the blood-brain barrier becomes re-established with the passage of time.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 3 , August 1989 , pp. 305 - 309
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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