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P300 in Behcet's Patients without Neurological Manifestations

Published online by Cambridge University Press:  02 March 2017

Hulusi Kececi  and
Melih Akyol
Hulusi Kececi*
Affiliation:
Department of Neurology, Medical Faculty of Cumhuriyet University, Sivas, Turkey
Melih Akyol
Affiliation:
Department of Dermatology, Medical Faculty of Cumhuriyet University, Sivas, Turkey
*
Mehmet Pasa M. Hersek S. Guldas Apt. No:1/6 58040-Sivas, Turkey.
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Abstract:

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Objective:

Behcet's disease is the association of recurrent aphthous stomatitis with genital ulceration and eye disease. Neurologic involvement patterns include meningomyelitis, a brain stem syndrome, pyramidal and extrapyramidal abnormality and stroke. In the present study, subclinical involvement was investigated by using P300 in Behcet's patients without neurological manifestation.

Methods:

Fifteen patients and 15 healthy volunteers were accepted for the study. P300 from vertex (Cz) electrode sites of the 10-20 system using electrodes and motor response time were recorded.

Results:

Patients had significantly prolonged latencies of P300 as compared to normal controls (p=0.013) but no significant differences in amplitude (p=1.000). Patients showed a significantly delayed motor response time than controls (p=0.006). Nine patients (60 %) had P300 latency and eight patients (53.3 %) had motor response time values exceeding the mean of controls by two standard deviations.

Conclusion:

The findings suggest that the P300 measures and motor response time may reflect subclinical neurologic involvement in Behcet's disease.

Résumé:

RÉSUMÉ:Objectif:

La maladie de Behcet comprend une stomatite aphteuse accompagnée d'ulcérations génitales et d'une maladie oculaire. L'atteinte neurologique inclut la méningomyélite, un syndrome du tronc cérébral, des anomalies pyramidales et extrapyramidales et l'accident vasculaire cérébral. Dans cette étude, l'atteinte subclinique a été investiguée au moyen de potentiels évoqués P300 chez des patients atteints de la maladie de Behcet sans manifestations neurologiques.

Méthodes:

Quinze patients et 15 volontaires sains ont été recrutés pour cette étude. les potentiels évoqués P300 de sites d'électrodes au vertex du système 10-20 utilisant des électrodes et le temps de la réponse motrice ont été enregistrés.

Résultats:

Les patients avaient des temps de latence P300 significativement prolongés comparés aux contrôles sains (p=0.013), sans différence significative de l'amplitude (p=1.000). Les patients avaient un temps de réponse motrice significativement retardé par rapport aux contrôles (p=0.006). Neuf patients (60%) avaient une latence P300 et huit patients (53.3%) avaient un temps de réponse motrice supérieur à deux déviations standards au-dessus de la moyenne des contrôles.

Conclusion:

Ces observations suggèrent que les mesures de potentiels évoqués P300 et le temps de réponse motrice pourraient refléter une atteinte neurologique subclinique dans la maladie de Behcet.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 28 , Issue 1 , February 2001 , pp. 66 - 69
Copyright
Copyright © The Canadian Journal of Neurological 2001

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