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The Neurobiological Substrates of Depression in Parkinson’s Disease: A Hypothesis

Published online by Cambridge University Press:  18 September 2015

H.C. Fibiger
H.C. Fibiger*
Affiliation:
Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver, B.C
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Abstract

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Evidence from a variety of sources indicates that the mesolimbic-mesocortical dopamine projections may play an important role in some types of reward or reinforcement processes in animals. There is circumstantial evidence that this is also true in humans. Since a reduced ability to experience pleasure or reward (i.e. anhedonia) is a cardinal feature of clinical depression, and since the mesolimbic and mesocortical dopamine projections have been shown to degenerate in Parkinson’s disease, it is suggested that damage to these reward-related systems may contribute directly to the high incidence of depression that has been reported in this disease.

Type
1. Neurotransmitters and the Pharmacology of the Basal Ganglia
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 105 - 107
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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