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Mechanisms of Tumor-Associated Edema: A Review

  • Rolando F. Del Maestro (a1), Joseph F. Megyesi (a1) and Catherine L. Farrell (a1)

Abstract:

An understanding of the mechanisms responsible for tumor-associated edema involves the elucidation of the role played by a number of intra-related processes. These include (i) the permeability of new tumor microvessels that are associated with tumor angiogenesis; (ii) alterations in microvascular permeability due to factors secreted by tumor cells; (iii) immunological mechanisms and (iv) increased microvessel permeability associated with inflammation. The rationale for a role for inflammatory processes in tumor-associated edema has been outlined and the role of non-steroidal anti-inflammatory drugs in modulating experimental and human tumor-associated edema has been explored.

RÉSUMÉ:

La compréhension des mécanismes responsables de l'oedème associé à des tumeurs implique Pélucidation du rôle de certains processus inter-reliés. Ce sont (I) la perméabilité des nouveaux microvaisseaux de la tumeur qui sont associés à l'angiogénèse tumorale; (II) les altérations de la perméabilité microvasculaire due à des facteurs sécrétés par les cellules tumorales; (III) des mécanismes immunologiques et (IV) une perméabilité accrue des microvaisseaux associée à l'inflammation. Nous justifions le rôle de processus inflammatoires dans l'oedème associé aux tumeurs et nous explorons le rôle des anti-inflammatoires non-stéroïdiens dans la modulation de l'oedème associé aux tumeurs, dans le contexte expérimental et humain.

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Copyright

Corresponding author

Brain Research Laboratories, Victoria Hospital, 375 South Street, London, Ontario, Canada N6A 4G5

References

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