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Laboratory Abnormalities in Polyneuropathy and Electrophysiological Correlations

  • Alon Abraham (a1), Ari Breiner (a1), Carolina Barnett (a1), Hans D. Katzberg (a1), Mylan Ngo (a1), Leif E. Lovblom (a2), Bruce A. Perkins (a2) and Vera Bril (a1)...

Abstract

To study the frequency of laboratory test abnormalities, and electrophysiological correlations, we performed a retrospective chart review of 226 patients with polyneuropathy. The frequency of laboratory test abnormalities, and correlations with electrophysiological findings were explored. Abnormal glucose handling tests were the most common findings (54%), followed by paraproteinemia (21%) and anemia (21%). The frequencies of paraproteinemia and anemia in our cohort were significantly higher than previously reported. In addition, several laboratory abnormalities correlated with electrophysiological findings of median neuropathy at the wrist, expanding current knowledge about the deleterious effects of various metabolic and hematologic derangements at this site.

Résultats anormaux à des tests de laboratoire dans le cas de la polyneuropathie et corrélations électro-physiologiques. Afin de comprendre la fréquence de résultats anormaux à des tests de laboratoire, nous avons mené une étude rétrospective des dossiers de 226 patients atteints de polyneuropathie. Nous avons à cet égard exploré les corrélations existant entre ces résultats anormaux et des observations de nature électro-physiologique. Des résultats anormaux à des tests de tolérance au glucose se sont révélés une des observations les plus courantes (54 %) ; on a ensuite obtenu des résultats anormaux à des tests pour la paraprotéinémie (21 %) et l’anémie (21 %). Les fréquences de paraprotéinémie et d’anémie dans notre cohorte étaient considérablement plus élevées que ce qui avait été signalé antérieurement dans la littérature. De plus, on a pu établir une corrélation entre de nombreux résultats anormaux à des tests et des observations électro-physiologiques se rapportant, au niveau du poignet, à des cas de neuropathie du nerf médian, ce qui permet d’élargir les connaissances actuelles quant aux effets néfastes de divers désordres métaboliques et hématologiques affectant cette région du corps.

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Copyright

Corresponding author

Correspondence to: Alon Abraham, Toronto General Hospital, 200 Elizabeth Street, Room 5 EB 309, Toronto, Ontario, Canada M5G 2C4. Email: alonabmail@gmail.com

References

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1. Martyn, CN, Hughes, RA. Epidemiology of peripheral neuropathy. J Neurol Neurosurg Psychiatr. 1997;62:310-318.
2. England, JD, Gronseth, GS, Franklin, G, et al. Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2005:199-207.
3. England, JD, Gronseth, GS, Franklin, G, et al. Practice parameter: evaluation of distal symmetric polyneuropathy: role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology. 2009:185-192.
4. Visser, NA, Notermans, NC, Linssen, RSN, van den Berg, LH, Vrancken, AFJE. Incidence of polyneuropathy in Utrecht, the Netherlands. Neurology. 2015;84:259-264.
5. Saleun, JP, Vicariot, M, Deroff, P, Morin, JF. Monoclonal gammopathies in the adult population of Finistère, France. J Clin Pathol. 1982;35:63-68.
6. Kyle, RA, Therneau, TM, Rajkumar, SV, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006;354:1362-1369.
7. Thomas, MC, MacIsaac, RJ, Tsalamandris, C, Power, D, Jerums, G. Unrecognized anemia in patients with diabetes: a cross-sectional survey. Diabetes Care. 2003;26:1164-1169.
8. Patel, KV. Epidemiology of anemia in older adults. Semin Hematol. 2008;45:210-217.
9. Papanas, N, Katsiki, N, Papatheodorou, K, et al. Peripheral neuropathy is associated with increased serum levels of uric acid in type 2 diabetes mellitus. Angiology. 2011;62:291-295.
10. Perkins, BA, Olaleye, D, Bril, V. Carpal tunnel syndrome in patients with diabetic polyneuropathy. Diabetes Care. 2002;25:565-569.
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Canadian Journal of Neurological Sciences
  • ISSN: 0317-1671
  • EISSN: 2057-0155
  • URL: /core/journals/canadian-journal-of-neurological-sciences
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