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Immunofluorescent Staining of Rat Brain Glial Cells With Multiple Sclerosis Serum

Published online by Cambridge University Press:  18 September 2015

Vuendra K. Singh  and
Robert D. Mashal
Vuendra K. Singh*
Affiliation:
Division of Immunology, Children’s Hospital, Vancouver, British Columbia
Robert D. Mashal*
Affiliation:
Division of Immunology, Children’s Hospital, Vancouver, British Columbia
*
Department of Pathology, Division of Neuropathology, Banting Institute, 100 College Street, Toronto, Ontario, M5G 11.5. Canada
Department of Pathology, Division of Neuropathology, Banting Institute, 100 College Street, Toronto, Ontario, M5G 11.5. Canada
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Antibodies directed against glial cells may be involved in autoimmunity in multiple sclerosis (MS). Using a tissue culture system, the presence of glial cell antibodies in MS-patient serum was detected through immunofluorescent technique. Thirty one of 73 MS-sera were strongly positive for anti-glial cells, 13 were equivocal and 29 were negative. The antibody staining was either cytoplasmic or associated with cell surface membrane, and involved IgG type of antibody.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 8 , Issue 2 , May 1981 , pp. 143 - 145
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

References

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