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Glucose and Insulin Metabolism in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

D. Shapcott ,
S. Melancon ,
R.F. Butterworth ,
K. Khoury ,
R. Collu ,
G. Breton ,
G. Geoffroy ,
B. Lemieux  and
A. Barbeau
D. Shapcott
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
S. Melancon
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
R.F. Butterworth
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
K. Khoury
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
R. Collu
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
G. Breton
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
G. Geoffroy
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
B. Lemieux
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
A. Barbeau*
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke; the Hôpital Ste-Justine, Montreal, the Clinical Research Institute of Montreal; and the Hôpital Hôtel-Dieu de Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, H2W 1R7 Montreal, Quebec, Canada
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Summary:

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Our prospective survey of 50 ataxic patients confirms the previous finding of frequent clinical or chemical diabetes in Friedreich's ataxia. Eighteen percent of our typical cases have clinical diabetes and 40% at least an abnormal glucose tolerance curve. However, this finding does not appear to be specific to that form of ataxia. Furthermore, we have shown that most patients with ataxia have normal or low fasting insulin levels, but a hyperinsulinic response to a glucose load.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 4 , November 1976 , pp. 361 - 364
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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