Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-24T10:51:38.954Z Has data issue: false hasContentIssue false
  • English
  • Français

Friedreich's Ataxia and Oral Glucose Tolerance: I. The effect of ingested glucose on serum glucose and insulin values in homozygotes, obligate heterozygotes and potential carriers of the Friedreich's ataxia gene.

Published online by Cambridge University Press:  18 September 2015

G. Tolis ,
A. Mehta ,
E. Andermann ,
C. Harvey  and
A. Barbeau
G. Tolis
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
A. Mehta
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
E. Andermann
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
C. Harvey
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
A. Barbeau*
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Glucose tolerance and insulin release were evaluated in 16 families with Friedrich's ataxia. Impaired glucose tolerance differed in incidence according to the method of evaluation, but was increased in number in parents' and siblings of Friedreich's cases. Insulin output was not quantitatively different from normal, although the insulin peak was often delayed. This finding, in association with impaired glucose tolerance, suggest a defect in glucose entry into cells.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 397 - 400
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES:

Andermann, E., Rèmillard, G.M., Goyer, C, Blitzer, LAndermann, F. and Barbeau, A. (1976). Genetic and family studies in Friedreich’s Ataxia. Can. J. Neuro. Sci., 3: 287–301.CrossRefGoogle ScholarPubMed
Caraceni, T., Panerai, A.E., Parati, E.A., Cocchi, D. and Muller, E.E. (1977). Altered GH and PRL responses to dopaminergic stimulation in Huntington’s chorea. J. Clin. Endocrinol. Metab., 44: 870–875.CrossRefGoogle ScholarPubMed
Collu, R., Geoffroy, GMelançon, S.B. and Barbeau, A. (1977). Growth hormone levels in Friedreich’s Ataxia. Horm. Metab. Res., 9: 523–524.CrossRefGoogle ScholarPubMed
Danowski, T.S. (1975). Classifications of Diabetes Mellitus in Endocrinology and Diabetes. The Thirtieth Hahnemann Symposiumeds. Kryston, L.J. Shaw, R A. pubs. Grune & Stratton, 321.32.Google Scholar
Draper, R., Shapcott, D., Larose, AStankova, l, Lévesque, F. and Lemieux, B. (1979). Glucose tolerance and erythrocyte insulin receptors in Friedreich’s Ataxia. Can. J. of Neuro. Sci., 6: 233–240.CrossRefGoogle ScholarPubMed
Geoffroy, G., Barbeau, A., Breton, G., Lemieux, B., Aubé, M., Léger, C. and Bouchard, J.P. (1976). Clinical description and roentgenologic evaluation of patients with Friedreich’s Ataxia. Can. J. Neuro. Sci., 3: 279–296.CrossRefGoogle ScholarPubMed
Keen, H., Jarrett, R.J. and Alberti, K.G.M.M. (1979). Diabetes Mellitus: A new look at diagnostic criteria. Diabetologia, 16: 283–285.CrossRefGoogle Scholar
Morgan, C.R. and Laza Row, A. (1963). Immunoassay of insulin: Two antibody system. Diabetes, 12: 115–126.CrossRefGoogle Scholar
Shapcott, D., Melançon, S., Butterworth, R.F., Khoury, KCollu, R., Breton, G., Geoffroy, G. and Lemieux, A. (1976). Glucose and insulin metabolism in Friedreich’s Ataxia. Can. J. of Neuro. Sci., 3: 361–364.CrossRefGoogle ScholarPubMed
Welburn, T., Rubenstein, A.H., Haslam, R. and Fraser, R. (1966). Normal insulin response to glucose. Lancet (1) 280–284.CrossRefGoogle Scholar